| Gene Symbol | TMX2 |
| Aliases | TMX2PROTEIN |
| Chromosome | 1 |
| Protein Type | Gene |
| Function | The protein's topology places its redox-active domain in the ER lumen, where it can interact with other ER-resident proteins involved in disulfide bond formation and protein folding. |
| Subcellular Localization | , or oxidative inactivation—ER proteostasis fails, leading to accumulation of protein aggregates. This dysfunction activ |
| Molecular Weight | 32 kDa |
| Pathways | Autophagy, Oxidative Stress, Mitophagy, CRISPR-Cas, autophagy pathway |
| GeneCards | TMX2 |
| Human Protein Atlas | TMX2 |
| Protein Disulfide Isomerase (PDI) | Closely related ER oxidoreductase with overlapping functions |
| Unfolded Protein Response (UPR) | Stress response pathway involving TMX2 regulation |
| ER-Associated Degradation (ERAD) | Quality control system dependent on proper disulfide bonding |
| Associated Diseases | Hepatocellular Carcinoma, Poor Prognosis |
| Interactions | AND, AUTOPHAGY, GAIN, GENES, HUMAN GENES, MITOCHONDRIA |
| KG Connections | 49 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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