protein 1,035 words KG: TWINKLEPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Twinkle (Mitochondrial DNA Helicase)

🔬 Protein Info
Gene SymbolTWNK
Full NameTwinkle mtDNA Helicase
Chromosome10q24.31
FunctionTwnk Gene plays an important role in the study of neurodegenerative diseases
Subcellular LocalizationMitochondrial nucleoid
Molecular Weight~77 kDa (monomer), ~462 kDa (hexamer)
PathwaysAutophagy, Mitophagy
UniProt IDQ96RR1
NCBI Gene ID56652
Ensembl IDENSG00000107815
OMIM604367
GeneCardsTWNK
Human Protein AtlasTWNK
Protein NameTwinkle (mitochondrial helicase)
GeneTWNK (PEO1, C10orf2)
Associated Diseasesneurodegeneration
InteractionsAND, MTDNA
KG Connections10 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in