gene

MTDNA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTDNA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1174Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

MTDNA is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 733 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MTDNA
Primary Expression	Spinal Cord
Pathways	Mitophagy, Nf-Κb, Oxidative Stress, Apoptosis, Autophagy
GeneCards	MTDNA
Human Protein Atlas	MTDNA
Associated Diseases	ALS, Aging, Alzheimer, Autism, Autoimmune
Interactions	MITOCHONDRIAL DNA, DNA, TFAM, HK2, JUN, LC3
KG Connections	1141 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MTDNA["MTDNA"] -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    MTDNA["MTDNA"] -->|"activates"| Als["Als"]
    MTDNA["MTDNA"] -->|"activates"| Inflammation["Inflammation"]
    MTDNA["MTDNA"] -->|"activates"| Aging["Aging"]
    MTDNA["MTDNA"] -->|"activates"| Ms["Ms"]
    MTDNA["MTDNA"] -->|"associated"| Carcinoma["Carcinoma"]
    TDP43["TDP43"] -->|"causes"| MTDNA["MTDNA"]
    STING["STING"] -->|"activates"| MTDNA["MTDNA"]
    CGAS["CGAS"] -->|"activates"| MTDNA["MTDNA"]
    GPX4["GPX4"] -->|"associated"| MTDNA["MTDNA"]
    style MTDNA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (721)

Target	Relation	Type	Str
DNA	activates	gene	1.00
Als	activates	disease	1.00
Inflammation	activates	disease	1.00
DNA	associated_with	gene	1.00
Mitochondrial Function	activates	pathway	1.00
Mitophagy	activates	pathway	1.00
STING	activates	gene	1.00
Oxidative Stress	activates	pathway	1.00
CGAS-STING	activates	gene	1.00
MITOCHONDRIA	activates	gene	1.00
MITOCHONDRIA	associated_with	gene	1.00
Autophagy	activates	pathway	1.00
Neuroinflammation	activates	disease	0.95
Cancer	therapeutic_target	disease	0.95
Neurodegeneration	activates	disease	0.95
Inflammation	inhibits	disease	0.95
CGAS	activates	protein	0.94
mitochondrial respiration	regulates	process	0.90
mitochondrial proteome	associated_with	protein	0.90
DNA	inhibits	gene	0.90
Aging	activates	disease	0.85
Cancer	activates	disease	0.85
Ischemia	inhibits	disease	0.85
Als	inhibits	disease	0.85
Als	therapeutic_target	disease	0.85
Neurodegeneration	associated_with	disease	0.85
Senescence	activates	disease	0.85
Als	associated_with	disease	0.85
Alzheimer	activates	disease	0.85
Parkinson	activates	disease	0.85
Nf-Κb	activates	pathway	0.80
Oxidative Stress	inhibits	pathway	0.80
Oxidative Stress	associated_with	pathway	0.80
GENES	activates	gene	0.80
Apoptosis	activates	pathway	0.80
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.80
AUTOPHAGY	activates	gene	0.80
AGING	activates	gene	0.80
GENES	associated_with	gene	0.80
Oxidative Phosphorylation	causes	pathway	0.80
Cardiac	activates	disease	0.75
Tumor	activates	disease	0.75
Diabetes	activates	disease	0.75
Hepatitis	activates	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
Tumor	causes	disease	0.75
Aging	inhibits	disease	0.75
Cancer	causes	disease	0.75
Cardiovascular	treats	disease	0.75

Incoming (453)

Source	Relation	Type	Str
CGAS	activates	gene	1.00
MITOCHONDRIAL DNA	associated_with	gene	1.00
MITOCHONDRIAL DNA	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	activates	gene	1.00
MITOPHAGY	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
ROS	activates	gene	1.00
PINK1	activates	gene	1.00
DNA	activates	gene	1.00
GENES	activates	gene	1.00
MITOCHONDRIAL DNA	causes	gene	1.00
oxidative stress	causes	process	0.90
APOPTOSIS	activates	gene	0.90
NEURODEGENERATIVE DISEASES	activates	gene	0.90
NEURODEGENERATION	activates	gene	0.90
GENES	associated_with	gene	0.80
NF-ΚB	activates	gene	0.80
CYTOKINES	activates	gene	0.80
PARKIN	activates	gene	0.80
AUTOPHAGY	activates	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
INFLAMMATION	inhibits	gene	0.80
NEUROINFLAMMATION	activates	gene	0.80
CANCER	therapeutic_target	gene	0.80
NEURODEGENERATION	associated_with	gene	0.80
TDP43	causes	protein	0.72
TFAM	activates	gene	0.70
AMPK	activates	gene	0.70
DNA	inhibits	gene	0.70
PTEN	activates	gene	0.70
MITOCHONDRIAL DNA	inhibits	gene	0.70
MITOCHONDRIAL DNA	therapeutic_target	gene	0.70
IRF3	activates	gene	0.70
IL-6	activates	gene	0.70
CGAS-STING	activates	gene	0.70
IRF3	inhibits	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
P62	activates	gene	0.70
PYROPTOSIS	activates	gene	0.70
GSDMD	activates	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.70
TFAM	expressed_in	gene	0.70
CANCER	associated_with	gene	0.70
CANCER	activates	gene	0.70
EXERCISE	activates	gene	0.70
SIRT1	activates	gene	0.70
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Re	0.581	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MTDNA

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Parthanatos in Neurodegeneration

Frontotemporal Dementia (FTD) Mechanistic Pathway

Pathway Diagram

Outgoing (721)

Incoming (453)

Targeting Hypotheses (1)

Mentioning Analyses (3)

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of TDP-43-induced mitochondrial DNA release for

Related Papers (0)

MTDNA

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Parthanatos in Neurodegeneration

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Alzheimer's Disease

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

oxidative-stress-comparison

Mitophagy Pathway in Neurodegeneration

rankings

Mitochondrial Dysfunction in Neurodegeneration

Epigenetic Alterations in Alzheimer's Disease

Gene-Mechanism-Therapy Causal Chains

Insulin Signaling in Parkinson's Disease

Non-Homologous End Joining in Neurodegeneration

DNA Damage Response in Parkinson's Disease

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Pathway Diagram

Outgoing (721)

Incoming (453)

Targeting Hypotheses (1)

Mentioning Analyses (3)

What upstream mechanisms cause TDP-43 to trigger mPTP opening and can this be th

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What determines the specificity of TDP-43-induced mitochondrial DNA release for

Related Papers (0)