| Gene Symbol | VPS4A |
| Full Name | Vacuolar Protein Sorting 4 Homolog A |
| Chromosome | 16q22.1 |
| Function | encodes an AAA+ ATPase involved in endosomal sorting, multivesicular body formation, and autophagy. |
| Molecular Weight | 48 kDa |
| Amino Acids | 437 aa |
| Pathways | Autophagosome-lysosome Fusion, Autophagy, autophagy pathway |
| UniProt ID | Q9Y5X0 |
| NCBI Gene ID | 27183 |
| Ensembl ID | ENSG00000167842 |
| OMIM | 609434 |
| GeneCards | VPS4A |
| Human Protein Atlas | VPS4A |
| Multivesicular body (MVB) biogenesis | VPS4A catalyzes the formation of intraluminal vesicles within multivesicular bodies, sequestering ubiquitinated cargo for lysosomal degradation |
| Cytokinesis | VPS4A participates in abscission, the final scission event during cell division, working alongside the ESCRT machinery |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | Aloperine |
| Interactions | SQSTM1, Rb, CANCER, APOPTOSIS, AUTOPHAGY, ROS |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsHPASTRING |