| Gene Symbol | PTPRN2 |
| Full Name | PTPRN2 — Protein Tyrosine Phosphatase Receptor Type N2 |
| Chromosome | 7q36.3 |
| Protein Type | Gene |
| Function | It regulates the phosphorylation state of synaptic proteins including: - NMDA receptor subunits - AMPA receptor trafficking proteins - Postsynaptic density scaffolds (PSD-95, PSD-93) |
| Primary Expression | neuroendocrine cells and neurons |
| Molecular Weight | 130 kDa |
| Pathways | MAPK, PI3K |
| GeneCards | PTPRN2 |
| Human Protein Atlas | PTPRN2 |
| Extracellular domain | Contains a tandem repeat of fibronectin type III domains involved in cell-cell adhesion and signaling |
| Single transmembrane helix | Anchors the protein to the plasma membrane |
| Brain | Cerebral cortex, hippocampus, cerebellum, and basal ganglia |
| Neuroendocrine tissues | Pancreatic islets, adrenal medulla, pituitary gland |
| Peripheral nervous system | Sensory and autonomic ganglia |
| Associated Diseases | Glioblastoma, Ms |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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