gene 1,483 words KG: SIGLEC1 2026-03-27
kind:genesection:genesstate:published
Contents

SIGLEC1 Gene

🧬 Gene Info
Gene SymbolSIGLEC1
Full NameSialic Acid-Binding Ig-Like Lectin 1
Chromosome20p13
Protein TypeReceptor
FunctionSialic Acid Recognition: Binds to sialylated glycans on host cells and pathogens
Molecular Weight185 kDa
Amino Acids1644 aa
UniProt ID[Q9PMN3](https://www.uniprot.org/uniprot/Q9PMN3)
Ensembl IDENSG00000105550
OMIM600738
GeneCardsSIGLEC1
Human Protein AtlasSIGLEC1
N-terminal V-type Ig domainContains the sialic acid-binding site
C2-type Ig domains (16 repeats)Form the stalk region
Mucin-like regionProvides extended structure
Associated Diseasesneurodegeneration
KG Connections46 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Tau Protein
protein · KG edge: co_discussed
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: co_discussed

Knowledge Graph (12 edges)

SIGLEC1 therapeutic_target SPR
SIGLEC1 therapeutic_target APOE
SIGLEC1 associated_with MAPK10
SIGLEC1 co_discussed SORL1
SIGLEC1 co_discussed SPI1
SIGLEC1 co_discussed TAU
SIGLEC1 co_discussed TMEM106B
SIGLEC1 co_discussed TREM2
SIGLEC1 therapeutic_target Diabetes
SIGLEC1 therapeutic_target Als