gene 2,688 words KG: CLU
Contents

CLU — Clusterin (Apolipoprotein J)

🧬 Gene Info
Gene SymbolCLU
Full NameClusterin (Apolipoprotein J, ApoJ)
AliasesPage for CLU Gene
Chromosome8p21.1
Functionis a gene located on chromosome 8p21.
Primary ExpressionHippocampus, Cortex, Basal ganglia, Cerebellum
Exons9
PathwaysAstrocyte Reactivity, Blood-Brain Barrier, Camp Signaling, Complement, Dysbiosis
UniProt IDP10909
NCBI Gene ID1115
Ensembl IDENSG00000120885
OMIM185551
GeneCardsCLU
Human Protein AtlasCLU
Associated DiseasesALS, ALZHEIMER'S DISEASE, Aging, Alzheimer, Alzheimer disease
InteractionsPPARGC1A, BAX, LC3, PPARG, C1Q, TREM2
KG Connections1059 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44

Related Analyses (7)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Extracellular vesicle biomarkers for early AD detection
neurodegeneration · completed
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
adam17
gene · KG edge: associated_with
ACTN2 — Actinin Alpha 2
gene · KG edge: regulates
ACE Gene
gene · KG edge: associated_with
ABI3 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CLU co_discussed LC3
CLU co_discussed STING
CLU phosphorylates TAU
CLU co_discussed MITOPHAGY
CLU phosphorylates PHAGOCYTOSIS
CLU provides_data_for ds-83b31ef18d49
CLU provides_data_for ds-db4a006ea647
CLU interacts_with PPARGC1A
CLU interacts_with BAX
CLU interacts_with LC3