gene 1,629 words KG: MAPK10 2026-03-24
kind:genesection:genesstate:published
Contents

MAPK10 Gene

🧬 Gene Info
Gene SymbolMAPK10
AliasesMitogen-Activated Protein Kinase 10
Chromosome5q36.3
Protein FamilyMAPK family, JNK subfamily
Protein TypeSerine/Threonine Kinase
FunctionRegulatory and interaction domains
Primary Expressionthe central nervous system and plays critical roles in stress responses, neuronal apoptosis, synaptic plasticity, and neurodegeneration
Molecular Weight52 kDa
Amino Acids464 aa
Exons21
PathwaysMAPK
NCBI Gene ID5602
GeneCardsMAPK10
Human Protein AtlasMAPK10
MKK4Phosphorylation
Associated Diseasesneurodegeneration
InteractionsJNK3, MAPT, PGR, PIK3R1, GENES, FERROPTOSIS
KG Connections55 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (4)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

JNK (c-Jun N-terminal Kinase) Protein
protein · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: regulates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: therapeutic_target
JNK3 (MAPK10)
gene · KG edge: activates

Knowledge Graph (12 edges)

MAPK10 therapeutic_target APOE
MAPK10 associated_with SIGLEC1
MAPK10 therapeutic_target SPR
MAPK10 activates JNK3
MAPK10 targets MAPT
MAPK10 targets SLC32A1
MAPK10 implicated_in MAPT
MAPK10 implicated_in SLC32A1
MAPK10 interacts_with MAPT
MAPK10 interacts_with PGR