| Gene Symbol | SPR |
| Protein Type | Enzyme |
| Function | GTP cyclohydrolase I (GCH1): GTP → 7,8-dihydroneopterin triphosphate |
| Subcellular Localization | Cytosolic |
| Pathways | Immune Response |
| Ensembl ID | ENSG00000166347 |
| GeneCards | SPR |
| Human Protein Atlas | SPR |
| Cofactor | NADPH |
| Reaction type | Two-step reduction (ketoreductase) |
| Subcellular localization | Cytosolic |
| Tissue distribution | Liver, brain, adrenal glands |
| Parkinson's Disease | BH4 metabolism altered in PD brains |
| Tyrosine hydroxylase deficiency | Related disorder |
| Associated Diseases | ALS, Ischemia, Ms |
| Interactions | HK2, TNF, NLRP3, LRP1, PARKIN, FER |
| KG Connections | 251 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |