Contents

SIRT4 Gene

🧬 Gene Info

Gene Symbol	SIRT4
Chromosome	12q24.31<br>
Function	SIRT4 is primarily mitochondrial and regulates several key metabolic processes
Molecular Weight	35 kDa
Pathways	Oxidative Stress
UniProt ID	Q9NWU1
NCBI Gene ID	23127
Ensembl ID	ENSG00000057394
GeneCards	SIRT4
Human Protein Atlas	SIRT4
ADP-Ribosylation	Catalyzes ADP-ribosylation of target proteins (primary activity)
Glutamine Metabolism	Regulates GDH (glutamate dehydrogenase) activity through ADP-ribosylation, inhibiting glutamine-dependent insulin secretion
fatty acid oxidation	Influences fatty acid metabolism in mitochondria
Mitochondrial DNA Replication	Interacts with TFAM and mitochondrial DNA polymerase
Insulin Secretion	Inhibits pancreatic beta-cell insulin secretion in response to amino acids
Associated Diseases	Alzheimer's Disease, Parkinson's Disease, Type 2 Diabetes, Cancer
Interactions	SIRT6, SIRT3
KG Connections	74 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph