gene 1,417 words KG: SIRT2 2026-03-27
kind:genesection:genestopic:parkinsonstopic:alzheimers
Contents

SIRT2 Gene

🧬 Gene Info
Gene SymbolSIRT2
Full NameSirtuin 2
Chromosome19q13.32
FunctionThis function is critical for
Primary Expressionboth cytoplasmic and nuclear compartments
Subcellular Localization**Primary**: Cytoplasm, where it deacetylates alpha-tubulin
Molecular Weight43 kDa
Amino Acids389 aa
Exons13 coding exons
PathwaysAutophagy, Necroptosis, Oxidative Stress
UniProt IDQ8IXJ6
NCBI Gene ID22933
Ensembl IDENSG00000145335
OMIM604479
GeneCardsSIRT2
Human Protein AtlasSIRT2
Associated DiseasesAGING, ALS, Alzheimer, Alzheimer'S Disease
Known Drugs/CompoundsMMP9_IN1
InteractionsTAU, FOXO1, NLRP3, ASC, AIM2, NLRC4
KG Connections287 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Sirtuin Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: inhibits

Knowledge Graph (12 edges)

SIRT2 activates NRF2
SIRT2 regulates NRF2
SIRT2 regulates MMP9
SIRT2 expressed_in SIRT3
SIRT2 regulates HDAC3
SIRT2 regulates HDAC6
SIRT2 expressed_in SIRT4
SIRT2 regulates HDAC7
SIRT2 expressed_in SIRT1
SIRT2 regulates HDAC1