gene 1,489 words KG: HDAC11 2026-03-28
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsonstopic:neuroinflammationtopic:epigenetics
Contents

HDAC11 Gene

🧬 Gene Info
Gene SymbolHDAC11
Full NameHDAC11
AliasesHistone Deacetylase 11
Chromosome3p25.2
Protein TypeGene
Functionencodes a protein of 347 amino acids with a molecular weight of approximately 39 kDa, making it the smallest mammalian HDAC.
Primary Expressionvarious brain regions including the cerebral cortex, hippocampus, cerebellum, and basal ganglia, with particular enrichment in neurons and, to a lesse
Molecular Weight39 kDa
Amino Acids347 aa
Exons13
PathwaysNF-κB
NCBI Gene IDSearch NCBI
GeneCardsHDAC11
Human Protein AtlasHDAC11
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsHDAC3, HDAC5, HDAC7
KG Connections62 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (11)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (3)

Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (9)

huntington-disease-treatment
therapeutic · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: regulates
HDAC7 Gene
gene · KG edge: expressed_in
HDAC3 Gene
gene · KG edge: expressed_in
HDAC2 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

HDAC11 expressed_in HDAC2
HDAC11 regulates SIRT7
HDAC11 regulates SIRT5
HDAC11 regulates BDNF
HDAC11 regulates SIRT1
HDAC11 expressed_in HDAC1
HDAC11 regulates SIRT2
HDAC11 regulates SIRT3
HDAC11 expressed_in HDAC3
HDAC11 expressed_in HDAC6