therapeutic 787 words KG: ent-gene-5f5bc4b3 2026-03-31
kind:therapeuticsection:therapeuticsstate:publishedtopic:cd73mechanism:purinergicdisease:alzheimers-diseasedisease:parkinsons-disease
Contents

CD73 (NT5E) Inhibitors for Neurodegeneration

🔬 Protein Info
Gene SymbolNT5E
Full NameEcto-5'-Nucleotidase
Chromosome6q14.3
Protein TypeEnzyme
FunctionAdenosine production, immune regulation
Primary Expressionthe central nervous system (CNS), where it modulates synaptic transmission, neuroinflammation, and blood-brain barrier (BBB) function
Molecular Weight70 kDa
Amino Acids320 aa
PathwaysLipid Metabolism
UniProt IDP21589
NCBI Gene ID4904
Ensembl IDENSG00000135318
OMIM602872
GeneCardsNT5E
Human Protein AtlasNT5E
Associated DiseasesALS, Alzheimer, dementia
KG Connections38 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Purinergic Signaling Dysfunction Validation in Parkinson's D
clinical · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses

Knowledge Graph (2 edges)

ent-gene-5f5bc4b3 data_in benchmark_ot_ad_answer_key:NT5E
benchmark_ot_ad_answer_key:NT5E data_in ent-gene-5f5bc4b3