| Gene Symbol | ent-gene-16cf4081 |
| Category | Microglia Modulation |
| Target | Colony-Stimulating Factor 1 Receptor (CSF1R) |
| Drug Class | Small molecule kinase inhibitors |
| Status | Preclinical and Phase 1/2 trials |
| Drug | Class |
| PLX3397 (Pexidartinib) | Kinase inhibitor |
| PLX5622 | AD |
| BLZ945 | ALS |
| GW2580 | Mouse |
| JNJ-40346527 | ALS |
| AXL-2009 | Kinase inhibitor |
| Adverse Event | Frequency |
| Liver enzyme elevation | Common |
| Fatigue | Common |
| Headache | Common |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |