therapeutic 3,030 words KG: ent-gene-16cf4081
section:therapeuticskind:therapeutictopic:parkinsons
Contents

CSF1R Inhibitors for Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-16cf4081
Chromosome5q32
GeneCSF1R, chromosome 5q32
Protein972 amino acids
Molecular weight~165 kDa (full-length)
LigandsCSF1 (M-CSF), IL-34
PathwayEffect
RAS/RAF/MEK/ERKProliferation, survival
PI3K/AKTSurvival, metabolism
PLCγCalcium signaling
JAK/STATTranscription activation
NF-κBInflammatory gene expression
DrugCompany
PLX5622Plexxikon/CarThera
PLX3397 (Pexidartinib)Plexxikon/Daiichi Sankyo
BLZ945Novartis
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (29)

TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
TREM2-mediated microglial tau clearance enhancement
Score: 0.49

Related Analyses (21)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (30)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40

See Also (15)

Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 4 hypotheses
Transdiagnostic Proteomic Changes in Neurodegeneration
mechanism · Pages share 4 hypotheses
Therapeutic Targets in Neurodegeneration
mechanism · Pages share 4 hypotheses
Sex Differences in Neurodegeneration
mechanism · Pages share 4 hypotheses
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 4 hypotheses