| Gene Symbol | ent-gene-c42d399b |
| Category | Angiogenesis / Neurovascular Therapy |
| Target | Parkinson's Disease |
| Mechanism | VEGF-mediated angiogenesis, BBB repair, neuroprotection |
| Development Stage | Preclinical to Phase 1 |
| Component | VEGF Effect |
| Endothelial Cells | Promote survival, enhance tight junctions |
| Pericytes | Support pericyte recruitment and function |
| Astrocytes | Stabilize end-foot coverage |
| Neurons | Direct trophic support via VEGFR-1 |
| Model | VEGF Effect |
| 6-OHDA rat | +40% TH+ neuron survival |
| MPTP mouse | Reduced DA neuron loss |
| α-syn model | Decreased aggregation |
| Agent | Mechanism |
| Cilostazol | PDE3 inhibitor, promotes angiogenesis |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |