mechanism 1,678 words KG: ent-gene-c42d399b 2026-04-01
evidence:strongmechanismmechanismspublishedcbspspvegfangiogenesisneurovascular
Contents

VEGF and Angiogenesis Dysregulation in CBS/PSP

🔬 Protein Info
Gene Symbolent-gene-c42d399b
VEGF-BRegulates vascular maintenance and endothelial cell survival through VEGFR-1 signaling
VEGF-C/DPrimarily regulate lymphatic angiogenesis via VEGFR-3
Basal ganglia40-60% reduction in VEGF-A immunoreactivity
Subthalamic nucleusSevere VEGF depletion correlating with neuronal loss
BrainstemMarked reduction in midbrain and pons
Motor cortexModerate decrease in cortical layers[@vegf2023]
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Retinal Vascular Microcirculation Rescue
Score: 0.54
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.50

Related Analyses (30)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Do tau strains or regional cellular environments primarily d
neurodegeneration · failed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (12)

Irisin treatment in mouse femur fracture healing model
validation · proposed · Score: 0.90
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40
CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omi
validation · proposed · Score: 0.40

See Also (15)

Yoga Therapy for Neurodegeneration
therapeutic · Pages share 3 hypotheses
YAP/TEAD Pathway Modulators for Neurodegeneration
therapeutic · Pages share 3 hypotheses
Wnt Signaling Modulators for Neurodegeneration
therapeutic · Pages share 3 hypotheses
vitamin-d-therapy-neurodegeneration
therapeutic · Pages share 3 hypotheses
Vitamin B Complex Therapy for Neurodegeneration
therapeutic · Pages share 3 hypotheses

Knowledge Graph (2 edges)

ent-gene-c42d399b data_in benchmark_ot_ad_answer_key:VEGF
benchmark_ot_ad_answer_key:VEGF data_in ent-gene-c42d399b