SciDEX — Wiki (38 pages)

The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases.

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Scientific World Model

What is the Scientific World Model?

⚙️ TDP-43 ProteinopathyKG

⚙️ TDP-43 Proteinopathy in Amyotrophic Lateral SclerosisKG

🔬 TAR DNA-Binding Protein 43 (TDP-43)KG

🔬 TDP-43 ProteinKG

🔬 Update TDP-43 protein page with comprehensive contentKG

🧫 Mechanism: Progranulin Loss and TDP-43 Pathology in FTDKG

⚙️ tdp-43-fus-rna-proteinopathy-comparisonKG

Therapeutic Hypothesis: TDP-43 and a-synuclein pathologies in the amygdala...KG

⚙️ VCP→TDP-43→ALS/FTD Causal ChainKG

⚙️ AD-FTD Tau-TDP-43 Overlap: Mechanism ComparisonKG

📊 TDP-43 (TAR DNA-Binding Protein 43) - BiomarkerKG

🔬 TARDBP Protein (TDP-43)KG

⚙️ TDP-43 Pathology in Corticobasal SyndromeKG

⚙️ TDP-43 Co-pathology in Corticobasal SyndromeKG

🏥 Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE)KG

⚙️ TDP-43 Proteinopathy in ALSKG

💡 Molecular Glue for TDP-43 Aggregate ClearanceKG

🏥 LATE (Limbic-Predominant Age-Related TDP-43 Encephalopathy)KG

⚙️ TDP-43 RNA Granule PathwayKG

⚙️ Cryptic Exon Splicing in TDP-43 ProteinopathyKG

⚙️ TDP-43 DNA Repair Mechanism in ALS and DementiaKG

⚙️ TDP-43 Pathology Reversibility in ALSKG

🔬 TARDBP/TDP-43 ProteinKG

💡 TDP-43 Splicing Modulation TherapyKG

🔬 TDP-43 Proteinopathy NeuronsKG

TDP-43 PET Ligand Development for Frontotemporal DementiaKG

🔬 TDP-43 Proteinopathy Neurons in Frontotemporal DementiaKG

🏥 TDP-43 Pathology in Corticobasal SyndromeKG

TDP-43 Proteinopathy Investment LandscapeKG

🧫 TDP-43 PET Ligand Development for FTD and ALSKG

Progranulin Deficiency and TDP-43 Aggregation in Frontotemporal DementiaKG

TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutation CarriersKG

↪️ TDP-43 ProteinKG

↪️ TDP-43 ProteinKG

🔬 TDP-43 ProteinKG

↪️ TDP-43 Proteinopathy NeuronsKG

Tau vs TDP-43 Fate Switching in Frontotemporal DementiaKG

🔬 TDP-43 Aggregate NeuronsKG