protein 660 words KG: TDP43PROTEIN 2026-03-24
kind:proteinsection:proteinsstate:published
Contents

TDP-43 Protein

🔬 Protein Info
Gene SymbolTDP
Full Name43 Protein
AliasesTDP43PROTEIN
Chromosome1p36.
FunctionTDP-43 is central to the pathogenesis of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and is commonly co-detected in Alzheimer's disease as a secondary pathology.
Subcellular Localizationsignal (
GeneCardsTDP
Human Protein AtlasTDP
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia
InteractionsGFAP, AKT, RAN, G3BP1, Rb, DNA
KG Connections251 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (19)

Cross-Seeding Prevention Strategy
Score: 0.45
p38α Inhibitor and PRMT1 Activator Combination to Restore Ph
Score: 0.61
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.60
PARP1 Inhibition Therapy
Score: 0.58
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56

Related Analyses (20)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
What determines the specificity of TDP-43-induced mitochondr
neurodegeneration · failed
How does chronic cGAS/STING activation downstream of TDP-43
neuroinflammation · failed
What mechanisms drive TDP-43 pathology specifically in Alzhe
neurodegeneration · failed
How does APOE4 mechanistically increase TDP-43 pathology fre
neurodegeneration · failed

Related Experiments (24)

cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95
TDP-43 mutant mouse model cGAS/STING pathway analysis
validation · proposed · Score: 0.90
TDP-43 mitochondrial invasion and DNA release via mPTP
exploratory · proposed · Score: 0.90
TDP-43 mitochondrial invasion and mtDNA release in iPSC moto
exploratory · proposed · Score: 0.90
cGAS/STING pathway validation in TDP-43 mutant mice
validation · proposed · Score: 0.85

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in