| Gene Symbol | TARDBP |
| Chromosome | 1p36 |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | RNA-binding and transcription regulation, challenging for small molecule targeting |
| Mechanism of Action | RNA-binding and transcription regulation, challenging for small molecule targeting |
| Subcellular Localization | </b></td><td>Nucleus (healthy), Cytoplasm (disease)</td></tr> |
| Druggability | Low (0.43) |
| Clinical Stage | Phase III |
| Molecular Weight | 43 kDa |
| Amino Acids | 4477 aa |
| Pathways | Apoptosis, Autophagy, Immune Response, Oxidative Stress, Tdp-43 |
| UniProt ID | A0A087WYY0 |
| GeneCards | TARDBP |
| Human Protein Atlas | TARDBP |
| Associated Diseases | AD, ALI, ALS, ALS-FTD, Alzheimer |
| Known Drugs/Compounds | Transcribed Rnas, RAPAMYCIN, rapamycin |
| Interactions | NTN1, SNRNP70, NTN3, ATG10, PINK1, LC3 |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | Cryptic Exon Silencing Restoration Cross-Seeding Prevention Strategy Glycine-Rich Domain Competitive Inhibition (+1 more) |
| KG Connections | 1201 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |