| Gene Symbol | TDP |
| Full Name | TAR DNA-Binding Protein 43 |
| Aliases | TDP43PROTEIN |
| Chromosome | 1p36 |
| Protein Type | RNA/DNA-binding protein (hnRNP family) |
| Function | TDP-43 is central to the pathogenesis of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and is commonly co-detected in Alzheimer's disease as a secondary pathology. |
| Subcellular Localization | signal ( |
| Molecular Weight | ~44 kDa (414 aa) |
| UniProt ID | Q7J653 |
| GeneCards | TDP |
| Human Protein Atlas | TDP |
| Gene | TARDBP |
| Key Diseases | ALS, FTD, Alzheimer's |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia |
| Interactions | GFAP, AKT, RAN, G3BP1, Rb, DNA |
| KG Connections | 251 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |