| Gene Symbol | TDP |
| Full Name | 43 (TAR DNA-Binding Protein 43) — Biomarker |
| Aliases | TDP43 |
| Chromosome | 1p36. |
| Function | TDP-43 is central to the pathogenesis of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and is commonly co-detected in Alzheimer's disease as a secondary pathology. |
| Subcellular Localization | signal ( |
| UniProt ID | Q7J653 |
| GeneCards | TDP |
| Human Protein Atlas | TDP |
| Gene | TARDBP (chromosome 1p36.22) |
| Protein | TDP-43, ~43 kDa |
| Sample Types | CSF, plasma, serum |
| Key Diseases | ALS, FTD, LATE, AD |
| CSF Sensitivity (ALS) | 70-90% |
| CSF Specificity (ALS vs. controls) | 80-90% |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia |
| Interactions | GFAP, AKT, RAN, G3BP1, Rb, DNA |
| KG Connections | 251 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |