protein 2,951 words KG: TDP43 2026-03-23
kind:proteinsection:proteinsstate:publishedevidence:strong
Contents

Update TDP-43 protein page with comprehensive content

🔬 Protein Info
Gene SymbolTARDBP
AliasesTAR DNA-binding protein 43
Chromosome1p36.2
Protein FamilyHeterogeneous nuclear ribonucleoprotein (hnRNP) family
Functionis a highly conserved RNA/DNA-binding protein encoded by the TARDBP gene on chromosome 1p36.
Primary ExpressionNucleus (physiological), cytoplasm (disease)
Subcellular LocalizationNucleus (physiological), cytoplasm (disease)
Molecular Weight43 kDa (414 amino acids)
Amino Acids414 aa
Exons2
PathwaysRNA metabolism, Stress granules, Protein aggregation
UniProt IDQ13148
GeneCardsTARDBP
Human Protein AtlasTARDBP
GeneTARDBP
Associated DiseasesALS, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia
InteractionsGFAP, AKT, RAN, G3BP1, Rb, DNA
KG Connections251 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (23)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
What determines the specificity of TDP-43-induced mitochondr
neurodegeneration · failed
How does chronic cGAS/STING activation downstream of TDP-43
neuroinflammation · failed
What mechanisms drive TDP-43 pathology specifically in Alzhe
neurodegeneration · failed
How does APOE4 mechanistically increase TDP-43 pathology fre
neurodegeneration · failed

Related Experiments (3)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (9)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: regulates
CTSD — Cathepsin D
gene · KG edge: associated_with
CSF1R — Colony Stimulating Factor 1 Receptor
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TDP43 activates CGAS
TDP43 activates MITOCHONDRIAL_DNA
TDP43 regulates STMN2
TDP43 inhibits AXONAL_REGENERATION
TDP43 regulates HERV_K
TDP43 associated_with TFEB
TDP43 associated_with TREM2
TDP43 associated_with VPS35
TDP43 regulates UNC13A
TDP43 causes UNC13A