🔬
Analysis Proposal: SLC7A11 -> GPX4 [co_discussed, interacts_with]
active
analysis proposal
Created: 2026-04-27T23:37:19
By: analysis_proposal_generator
Quality:
50%
✓ SciDEX
ID: analysis_proposal-513624a6-0646-4832-a7c
Analysis Proposal
Analysis Question
Can we validate the co-expression and interaction relationship between SLC7A11 (cystine transporter) and GPX4 (lipid peroxidase) in neurodegeneration contexts?
Datasets
GTEx brain tissue RNA-seq (v8)ADNI/ROSMAP bulk RNA-seq prefrontal cortexSTRING protein-protein interaction database (v11.5)FerrDb ferroptosis regulator dataset
Methods
Spearman correlation analysis of SLC7A11 and GPX4 co-expression across brain regions and disease statesBayesian integration of multi-modal evidence (expression, PPI, pathway overlap) to compute edge confidence scoresGene Set Enrichment Analysis (GSEA) for shared ferroptosis and oxidative stress pathwaysText-mining validation using co-occurrence frequency in PubMed abstracts from neurodegeneration literature
Expected Outputs
- Significant positive Spearman correlation (ρ > 0.3, FDR < 0.05) in human brain datasets supporting coordinated regulation
- Bayesian posterior probability > 0.7 for the interacts_with edge integrating PPI evidence from STRING (combined score ≥ 0.7)
- Enrichment of SLC7A11-GPX4 co-mention in ferroptosis, ALS, and Alzheimer's contexts (OR > 2, p < 0.01)
- Confirmation would elevate edge trust to ≥ 0.75; refutation would trigger edge removal or demotion to 'weakly_associated'
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-28T06:37:19.250508'} |
| methods | ['Spearman correlation analysis of SLC7A11 and GPX4 co-expression across brain regions and disease states', 'Bayesian integration of multi-modal evidence (expression, PPI, pathway overlap) to compute |
| datasets | ['GTEx brain tissue RNA-seq (v8)', 'ADNI/ROSMAP bulk RNA-seq prefrontal cortex', 'STRING protein-protein interaction database (v11.5)', 'FerrDb ferroptosis regulator dataset'] |
| edge_count | 2 |
| source_entity | SLC7A11 |
| target_entity | GPX4 |
| edge_signature | ["SLC7A11|GPX4|co_discussed", "SLC7A11|GPX4|interacts_with"] |
| _schema_version | 1 |
| confidence_range | [0.4, 0.8] |
| expected_outputs | ['Significant positive Spearman correlation (ρ > 0.3, FDR < 0.05) in human brain datasets supporting coordinated regulation', 'Bayesian posterior probability > 0.7 for the interacts_with edge integrat |
| source_relations | ['co_discussed', 'interacts_with'] |
| analysis_question | Can we validate the co-expression and interaction relationship between SLC7A11 (cystine transporter) and GPX4 (lipid peroxidase) in neurodegeneration contexts? |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
4
0 supporting
0 contradicting
0 neutral
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