gene

SLC7A11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC7A11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1404Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

SLC7A11 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 649 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	SLC7A11
Full Name	Solute Carrier Family 7 Member 11 (xCT)
Chromosome	4q28.3
Protein Type	Transporter
Target Class	Transporter
Function	Small molecule inhibition of cystine/glutamate exchange
Mechanism of Action	Small molecule inhibition of cystine/glutamate exchange
Primary Expression	various brain cell types:
Druggability	Medium (0.55)
Clinical Stage	Approved
Pathways	Akt, Autophagy, Epigenetic, Ferroptosis, Glutathione Biosynthesis
UniProt ID	Q9UPY5
Ensembl ID	ENSG00000155511
GeneCards	SLC7A11
Human Protein Atlas	SLC7A11
Associated Diseases	ALS, CANCER, CARCINOMA
Known Drugs/Compounds	alphaKG, ROS, SORAFENIB, kynurenine, icariin, paricalcitol
Interactions	GPX4, SIRT3, NRF2, NCOA4, BECN1, DES
SciDEX Target	View Target Profile (4 clinical trials)
KG Connections	1404 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SLC7A11 — AlphaFold Q9UPY5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    SLC7A11(["SLC7A11"])
    ferroptosis("ferroptosis")
    ROS(["ROS"])
    GPX4(["GPX4"])
    FERROPTOSIS(["FERROPTOSIS"])
    Ferroptosis["Ferroptosis"]
    Cancer["Cancer"]
    Als["Als"]
    Tumor["Tumor"]
    P53(["P53"])
    CANCER(["CANCER"])

    SLC7A11 -.->|"inhibits"| ferroptosis
    SLC7A11 -.->|"inhibits"| ROS
    SLC7A11 -->|"regulates"| GPX4
    SLC7A11 -.->|"inhibits"| FERROPTOSIS
    SLC7A11 -->|"activates"| GPX4
    SLC7A11 -->|"activates"| Ferroptosis
    SLC7A11 -.->|"inhibits"| GPX4
    SLC7A11 -.->|"inhibits"| Ferroptosis
    SLC7A11 -->|"activates"| Cancer
    SLC7A11 -->|"activates"| Als
    SLC7A11 -->|"activates"| Tumor
    SLC7A11 -->|"activates"| P53
    SLC7A11 -->|"activates"| FERROPTOSIS
    SLC7A11 -->|"activates"| CANCER
    SLC7A11 -->|"activates"| ROS

    style SLC7A11 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (794)

Target	Relation	Type	Str
ferroptosis	inhibits	phenotype	1.00
GPX4	regulates	protein	1.00
GPX4	activates	gene	1.00
GPX4	inhibits	gene	1.00
ROS	inhibits	drug	1.00
FERROPTOSIS	inhibits	phenotype	1.00
Ferroptosis	activates	pathway	1.00
Ferroptosis	inhibits	pathway	1.00
Cancer	activates	disease	1.00
Als	activates	disease	1.00
Tumor	activates	disease	1.00
P53	activates	gene	1.00
FERROPTOSIS	activates	gene	1.00
CANCER	activates	gene	1.00
ROS	activates	gene	1.00
Alpha-Ketoglutarate	upregulates	compound	0.90
Nonalcoholic Steatohepatitis	protects_against	disease	0.90
Liver Inflammation	inhibits	process	0.90
Liver Fibrosis	protects_against	disease	0.90
Cystine Import	mediates	process	0.90
Ferroptosis Suppression	involved_in	process	0.90
Chondrocyte Ferroptosis	inhibits	process	0.90
Ferroptosis Resistance	mediates	phenotype	0.90
ferroptosis	participates_in	pathway	0.90
ROS	downregulates	process	0.90
NASH	protects_against	disease	0.90
unfolded protein response	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
NRF2	activates	gene	0.90
Apoptosis	activates	pathway	0.90
Ferroptosis	regulates	pathway	0.90
OXIDATIVE STRESS	inhibits	gene	0.90
FERROPTOSIS	regulates	gene	0.90
APOPTOSIS	activates	gene	0.90
Glutathione Biosynthesis	regulates	pathway	0.88
Tumor Growth	associated_with	phenotype	0.88
FERROPTOSIS	protects_against	entity	0.88
NASH Progression	protects_against	disease	0.85
Hepatic Stellate Cell Ferroptosis	involved_in	process	0.85
Kynurenine	associated_with	compound	0.85
Als	therapeutic_target	disease	0.85
Cancer	inhibits	disease	0.85
Carcinoma	activates	disease	0.85
Als	regulates	disease	0.85
Tumor	inhibits	disease	0.85
Tumor	therapeutic_target	disease	0.85
Colorectal Cancer	activates	disease	0.85
Neurodegeneration	activates	disease	0.85
Ferroptosis	protects_against	process	0.85
Ferroptosis	suppresses	process	0.85

Incoming (610)

Source	Relation	Type	Str
TMEM16F	regulates	gene	1.00
NRF2	upregulates	protein	0.95
STAT6	upregulates	gene	0.95
FOXK2	upregulates	protein	0.95
BECN1	inhibits	protein	0.90
Rotenone	downregulates	compound	0.90
NFE2L2	upregulates	gene	0.90
GPX4	co_mentioned_with	gene	0.90
Klebsiella Pneumoniae	downregulates	disease	0.90
h-7957bb2a	targets_gene	hypothesis	0.90
Klebsiella pneumoniae	downregulates	disease	0.85
FOXO3	binds	protein	0.85
FOXO3	downregulates	protein	0.85
INTERLEUKIN-1 BETA	downregulates	protein	0.85
Paricalcitol	upregulates	drug	0.85
SIK1	correlates_with	gene	0.85
h-7957bb2a	targets	hypothesis	0.80
TP53	downregulates	entity	0.80
GPX4	treats	gene	0.80
ACSL4	co_mentioned_with	gene	0.80
Nrf2	regulates	protein	0.72
FOXK2	regulates	protein	0.72
GPX4	associated_with	gene	0.70
JAK2	regulates	protein	0.70
JNK	upregulates	protein	0.70
PI3K	inhibits	gene	0.70
ALOX12	activates	gene	0.70
C-JUN	upregulates	protein	0.70
FERROPTOSIS	destabilizes	phenotype	0.70
FOXO3	interacts_with	gene	0.65
FERROPTOSIS	causes	phenotype	0.65
OGD_R	inhibits	phenotype	0.64
c_Jun	regulates	protein	0.64
ETV4	regulates	protein	0.64
HIF1A	regulates	protein	0.64
kynurenine	interacts_with	drug	0.64
icariin	activates	drug	0.64
IL1B	inhibits	gene	0.64
paricalcitol	activates	drug	0.64
STAT6	activates	protein	0.64
MAP1LC3B	associated_with	gene	0.60
BMAL1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
ARNTL	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
JUN	activates	gene	0.60
NLRP3	expressed_in	gene	0.60
MMP3	activates	gene	0.60
GPX4	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SLC7A11

Understanding Entity Pages

Summary

Wiki Pages (21)

SLC7A11 Gene - xCT Cystine/Glutamate Antiporter

Ferroptosis in Alzheimer's Disease

Cellular Senescence in Neurodegeneration

Ferroptosis in Neurodegeneration

Iron Homeostasis Dysregulation in Neurodegeneration

Ferroptotic Neurons

Riluzole ALS Trials

epigenetics-neurodegeneration

ALS Regional Onset and Spread: Network-Level Staging Model

Glutathione Metabolism Pathway

ER Stress in Corticobasal Syndrome

PSP Ferroptosis and Iron-Dependent Cell Death

Ferroptosis

Ferroptosis in Alzheimer's Disease

Ferroptosis Pathway in Neurodegeneration

Ferroptosis Pathway in Neurodegeneration

POLG2 Gene — DNA Polymerase Gamma 2, Accessory Subunit

Section 191: Advanced Lipid Signaling Modulators in CBS/PSP

Ferroptosis and Lipid Peroxidation in 4R-Tauopathies

POLG — DNA Polymerase Subunit Gamma