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P2rx7 genetic deletion in PS19 tauopathy mice

experiment Created: 2026-04-12 18:03:51 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-1cc19685-9901-4bc4-a1f3-b
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Related Entities
P2rx7
Metadata
experiment_typeanimal_model
protocolGenetic deletion of P2rx7 in PS19 mice followed by behavioral testing, histological analysis, and tau protein quantification
expected_outcomesP2rx7 deletion would reduce brain atrophy, tau accumulation, and cognitive deficits
success_criteriaSignificant reduction in pathological markers and improved cognitive performance in P2rx7-deleted mice
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-12T11:03:51.877213
source_pmid40678243
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-12T18:03:51.883080'}
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Linked Artifacts (23)
related🧫P2rx7 congenic mouse model insulin tolerance testing100%
related🧫BDEV injection and recipient microglial transcriptome analys100%
related🧫P2rx7 congenic mouse model glucose tolerance testing100%
related🧫Single-cell RNA sequencing of mouse brains100%
related🧫P2RX7 variant rs1718119 association with glucose homeostasis100%
mentions📖p2rx780%
mentions📖P2RX7 Protein80%
related📖p2rx772%
related📖P2RX7 Protein72%
mentions📖Alzheimer's Disease60%
mentions📖brain-regions60%
mentions📖researchers60%
mentions📖TH Gene60%
mentions📖Tau Protein60%
mentions📖Tauopathy60%
related📖Alzheimer's Disease60%
related📖neuroinflammation55%
related📖Alzheimer's Disease54%
related📖brain-regions54%
related📖researchers54%
related📖TH Gene54%
related📖Tau Protein54%
related📖Tauopathy54%

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