🧫

BDEV injection and recipient microglial transcriptome analysis

experiment Created: 2026-04-12 18:03:52 By: experiment_extractor Quality: 80% ✓ SciDEX ID: experiment-exp-a7eb292f-c0d7-497d-a55b-f
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Related Entities
P2rx7
Metadata
experiment_typeanimal_model
protocolStereotactic injection of BDEVs, single-cell RNA sequencing of recipient brain tissue, pathway enrichment analysis
expected_outcomesBDEVs from P2rx7-expressing mice would induce stronger inflammatory responses in recipient microglia
success_criteriaEnrichment of DNA-sensing and interferon signaling pathways in response to P2rx7-containing BDEVs
sample_sizeNone
statistical_methodsSingle-cell transcriptomics and pathway enrichment analysis
p_valueNone
effect_sizeNone
extracted_at2026-04-12T11:03:51.877226
source_pmid40678243
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-12T18:03:52.397030'}
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Linked Artifacts (133)
related🧫P2rx7 genetic deletion in PS19 tauopathy mice100%
related🧫Cell type-specific P2rx7 deletion in microglia vs astrocytes100%
related🧫Brain-derived extracellular vesicles proteome analysis100%
related🧫P2rx7 congenic mouse model insulin tolerance testing100%
related🧫P2rx7 congenic mouse model glucose tolerance testing100%
related🧫Single-cell RNA sequencing of mouse brains100%
related🧫P2RX7 variant rs1718119 association with glucose homeostasis100%
mentions📖p2rx780%
mentions📖P2RX7 Protein80%
related📖p2rx772%
related📖P2RX7 Protein72%
mentions📖DNA Methylation Biomarkers in Neurodegeneration70%
mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration70%
mentions📖DNA Damage and Repair in Neurons70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Methylation70%
mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#70%
mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 70%
mentions📖DNA Damage Repair Therapy - Biomarker Guided70%
mentions📖DNA Damage Repair Investment Landscape70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖dna-damage-repair70%
mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas70%
mentions📖DNA Damage Response Impairment Pathway70%
mentions📖DNA Damage Response in 4R-Tauopathies70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Damage Response and Repair in Neurodegeneration70%
mentions📖DNA Damage Response in Neurons70%
mentions📖DNA Damage Response in Parkinson's Disease70%
mentions📖DNA Damage Response in Neurodegeneration70%
mentions📖DNA Methylation in Neurodegeneration70%
mentions📖DNA Repair Mechanisms in Neurodegeneration70%
mentions📖DNA Sensing Pathways in Neurodegeneration70%
mentions📖DNA Damage and Repair Dysfunction in PSP70%
mentions📖DNA Ligase III Protein70%
mentions📖DNA Ligase IV Protein70%
mentions📖DNA-PKcs (PRKDC) Protein70%
mentions📖DNA Damage Repair Therapy for Neurodegeneration70%
mentions📖DNA Repair Therapy for Neurodegeneration70%
mentions📖RNA Binding Fox-1 Homolog 1 (RBFOX1)70%
mentions📖RNA Binding Fox-1 Homolog 2 (RBFOX2)70%
mentions📖RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)70%
mentions📖RNA Therapeutics: Investment Landscape Analysis70%
mentions📖RNA Therapeutics for Neurodegeneration Investment Landscape70%
mentions📖RNA Metabolism Dysfunction in Corticobasal Syndrome70%
mentions📖RNA Metabolism Dysregulation in Alzheimer's Disease70%
mentions📖RNA G-quadruplexes in Neurodegeneration70%
mentions📖RNA Granule Dysfunction in Neurodegeneration70%
mentions📖RNA Metabolism in Neurodegeneration70%
mentions📖RNA Metabolism Dysregulation in 4R-Tauopathies70%
mentions📖RNA Metabolism in Alzheimer's Disease70%
mentions📖RNA Metabolism Dysregulation Pathway70%
mentions📖RNA Processing in Neurodegeneration70%
mentions📖RNA Splicing in Neurodegeneration70%
mentions📖RNA Splicing Dysregulation in 4R-Tauopathies: A Comparative 70%
mentions📖RNA Splicing Defects in Neurodegeneration70%
mentions📖RNA Stability and Decay70%
mentions📖RNA-Targeted Therapies in Neurodegeneration70%
mentions📖RNA-Targeted Therapeutics Investment Synthesis70%
mentions📖RNA Toxicity Pathway70%
mentions📖RNA Editing Therapeutics70%
mentions📖RNA-Based Therapeutics for Alzheimer's Disease70%
mentions📖RNA-Targeting Therapies for Neurodegenerative Diseases70%
mentions📖RNA Targeting Therapy for Neurodegeneration70%
mentions📖RNA-Based Therapeutics for Neurodegenerative Diseases70%
mentions📖RNA Interference (RNAi) Therapies for Neurodegeneration70%
related📖DNA Methylation Biomarkers in Neurodegeneration63%
related📖DNA Damage-Accumulating Neurons in Neurodegeneration63%
related📖DNA Damage and Repair in Neurons63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Methylation63%
related📖DNA Damage Repair Deficiency Validation Study in Parkinson&#63%
related📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 63%
related📖DNA Damage Repair Therapy - Biomarker Guided63%
related📖DNA Damage Repair Investment Landscape63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖dna-damage-repair63%
related📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas63%
related📖DNA Damage Response Impairment Pathway63%
related📖DNA Damage Response in 4R-Tauopathies63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Damage Response and Repair in Neurodegeneration63%
related📖DNA Damage Response in Neurons63%
related📖DNA Damage Response in Parkinson's Disease63%
related📖DNA Damage Response in Neurodegeneration63%
related📖DNA Methylation in Neurodegeneration63%
related📖DNA Repair Mechanisms in Neurodegeneration63%
related📖DNA Sensing Pathways in Neurodegeneration63%
related📖DNA Damage and Repair Dysfunction in PSP63%
related📖DNA Ligase III Protein63%
related📖DNA Ligase IV Protein63%
related📖DNA-PKcs (PRKDC) Protein63%
related📖DNA Damage Repair Therapy for Neurodegeneration63%
related📖DNA Repair Therapy for Neurodegeneration63%
related📖RNA Binding Fox-1 Homolog 1 (RBFOX1)63%
related📖RNA Binding Fox-1 Homolog 2 (RBFOX2)63%
related📖RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)63%
related📖RNA Therapeutics: Investment Landscape Analysis63%
related📖RNA Therapeutics for Neurodegeneration Investment Landscape63%
related📖RNA Metabolism Dysfunction in Corticobasal Syndrome63%
related📖RNA Metabolism Dysregulation in Alzheimer's Disease63%
related📖RNA G-quadruplexes in Neurodegeneration63%
related📖RNA Granule Dysfunction in Neurodegeneration63%
related📖RNA Metabolism in Neurodegeneration63%
related📖RNA Metabolism Dysregulation in 4R-Tauopathies63%
related📖RNA Metabolism in Alzheimer's Disease63%
related📖RNA Metabolism Dysregulation Pathway63%
related📖RNA Processing in Neurodegeneration63%
related📖RNA Splicing in Neurodegeneration63%
related📖RNA Splicing Dysregulation in 4R-Tauopathies: A Comparative 63%
related📖RNA Splicing Defects in Neurodegeneration63%
related📖RNA Stability and Decay63%
related📖RNA-Targeted Therapies in Neurodegeneration63%
related📖RNA-Targeted Therapeutics Investment Synthesis63%
related📖RNA Toxicity Pathway63%
related📖RNA Editing Therapeutics63%
related📖RNA-Based Therapeutics for Alzheimer's Disease63%
related📖RNA-Targeting Therapies for Neurodegenerative Diseases63%
related📖RNA Targeting Therapy for Neurodegeneration63%
related📖RNA-Based Therapeutics for Neurodegenerative Diseases63%
related📖RNA Interference (RNAi) Therapies for Neurodegeneration63%
mentions📖brain-regions60%
mentions📖Microglia60%
mentions📖Microglia60%
mentions📖researchers60%
related📖Alzheimer's Disease60%
related📖Alzheimer's Disease54%
related📖brain-regions54%
related📖Microglia54%
related📖Microglia54%
related📖researchers54%