gene

P2RX7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RX7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

600Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

1Experiments

Summary

P2RX7 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Aging, Als. Connected to 135 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	P2RX7
Full Name	Purinergic Receptor P2X Ligand-Gated Ion Channel 7
Chromosome	12
Protein Type	Ion Channel
Target Class	Ion Channel
Function	Selective P2X7 receptor antagonists blocking ATP-gated ion channel
Mechanism of Action	Selective P2X7 receptor antagonists blocking ATP-gated ion channel
Druggability	High (0.80)
Clinical Stage	Phase II
Molecular Weight	68.6 kDa
Amino Acids	595 aa
Pathways	Glucose Metabolism, Lipid Metabolism, Phagocytosis, tau accumulation, tau propagation
UniProt ID	Q99572
NCBI Gene ID	10278
Ensembl ID	ENSG00000088038
OMIM	601636
GeneCards	P2RX7
Human Protein Atlas	P2RX7
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, Autoimmune
Known Drugs/Compounds	therapeutic_target
Interactions	P2RY1, P2RX5, PANX1, P2X7, ADORA2B, P2RX4
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	P2RX7-Mediated Exosome Secretion Blockade
KG Connections	600 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — P2RX7 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5U1L — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q99572 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

P2RX7 Gene

gene · 2363 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    P2RX7["P2RX7"] -->|"associated"| neurodegeneration["neurodegeneration"]
    P2RX7["P2RX7"] -->|"interacts"| P2RY1["P2RY1"]
    P2RX7["P2RX7"] -->|"co discussed"| DGAT1["DGAT1"]
    P2RX7["P2RX7"] -->|"co discussed"| C3["C3"]
    P2RX7["P2RX7"] -->|"co discussed"| AQP4["AQP4"]
    P2RX7["P2RX7"] -->|"co discussed"| EPHB4["EPHB4"]
    P2RY1_1["P2RY1"] -->|"interacts"| P2RX7["P2RX7"]
    BMAL1["BMAL1"] -->|"co discussed"| P2RX7["P2RX7"]
    HK2["HK2"] -->|"co discussed"| P2RX7["P2RX7"]
    MIRO1["MIRO1"] -->|"co discussed"| P2RX7["P2RX7"]
    style P2RX7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (366)

Target	Relation	Type	Str
LUNG TISSUE	expressed_in	entity	0.95
UPREGULATES	upregulates	entity	0.95
Extracellular Vesicles	regulates	mechanism	0.95
Glucose Homeostasis	regulates	phenotype	0.93
GLUCOSE HOMEOSTASIS	regulates	entity	0.90
PANCREATIC B-CELLS	expressed_in	entity	0.90
purinergic signaling	involved_in	pathway	0.90
extracellular nucleotide signaling	involved_in	pathway	0.90
IMMUNE CELLS	expressed_in	entity	0.90
THERAPEUTIC_TARGET	therapeutic_target	entity	0.90
Neurodegeneration	contributes_to	process	0.90
Brain Atrophy	contributes_to	phenotype	0.90
pancreatic beta cells	expressed_in	cell_type	0.88
Lung Tissue	expressed_in	cell_type	0.85
Glucose Homeostasis	associated_with	process	0.85
COVID-19	upregulates	disease	0.85
Diabetes	risk_factor_for	disease	0.85
Glucose Metabolism	regulates	pathway	0.80
Glycemic Traits	associated_with	phenotype	0.80
neurons	expressed_in	cell_type	0.80
Type 2 Diabetes Mellitus	associated_with	disease	0.75
Type 2 Diabetes	associated_with	disease	0.75
P2RY12	inhibits	gene	0.70
neurodegeneration	associated_with	disease	0.66
P2RY1	interacts_with	gene	0.66
TAU	impairs	gene	0.65
TAU	inhibits	gene	0.65
TAU	mediates	gene	0.65
ASTHMA	targets	disease	0.65
TAU	treats	protein	0.65
Als	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Diabetes	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Depression	associated_with	disease	0.65
Autoimmune	associated_with	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Aging	activates	disease	0.65
Anxiety	activates	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Ms	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Covid	activates	disease	0.65
ALS	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65

Incoming (234)

Source	Relation	Type	Str
h-1333080b	targets_gene	hypothesis	0.90
h-0758b337	targets	hypothesis	0.80
P2RY1	interacts_with	gene	0.66
P2X7	inhibits	gene	0.65
IL18	inhibits	gene	0.65
ENTORHINAL CORTEX	inhibits	brain_region	0.65
ATP	inhibits	gene	0.65
EPILEPSY	produces	disease	0.65
P2RX1	therapeutic_target	gene	0.60
P2RX4	therapeutic_target	gene	0.60
ADORA2B	activates	gene	0.60
P2RY12	activates	gene	0.60
P2RX1	activates	gene	0.60
P2RX4	activates	gene	0.60
P2RY1	protects_against	gene	0.60
P2X7	associated_with	gene	0.60
SGK1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
A2M	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
GAIN	expressed_in	gene	0.60
CAMKK2	expressed_in	gene	0.60
P2X7	activates	gene	0.60
P2RY1	therapeutic_target	gene	0.60
P2RY14	therapeutic_target	gene	0.60
P2RY1	activates	gene	0.60
P2RX4	protects_against	gene	0.60
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
CD38	associated_with	gene	0.60
P2RY14	expressed_in	gene	0.60
P2RY1	expressed_in	gene	0.60
P2RX1	expressed_in	gene	0.60
P2RX5	activates	gene	0.60
PANX1	activates	gene	0.60
P2RX4	expressed_in	gene	0.60
ADORA2B	regulates	entity	0.60
P2RX1	regulates	entity	0.60
P2RX4	regulates	entity	0.60
P2RX5	regulates	entity	0.60
P2RX4	associated_with	entity	0.60
P2X7	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
P2RX7-Mediated Exosome Secretion Blockade	0.512	neurodegeneration	Tau propagation mechanisms and therapeut

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
P2RX7 variant rs1718119 association with glucose homeostasis in Botnia	exploratory	type 2 diabetes	0.900	0.00	human patients	proposed	N/A

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
cGAMP promotes inner blood-retinal barrier breakdown through P2RX7-mediated tran [PMID:40025497]	Ge X, Zhu X, Liu W, Li M, Zhang Z et al.	J Neuroinflammation	2025
Clemastine fumarate accelerates accumulation of disability in progressive multip [PMID:40371642]	Kocot J, Kosa P, Ashida S, Pirjanian NA,	J Clin Invest	2025
CRISP3-PSP94 complex regulates P2RX7 mediated signalling in prostate cancer cell [PMID:40473221]	Miya V, Pathak BR	Biochim Biophys Acta Mol Cell	2025
P2RX7 regulates tauopathy progression via tau and mitochondria loading in extrac [PMID:40678243]	Ikezu T, Bodart-Santos V, Ravula AR, You	Res Sq	2025
Tissue-resident memory CD4(+) T cells infiltrate the CNS in progressive multiple [PMID:40700520]	Pignata A, Frieser D, Gonzalez-Fierro C,	Sci Transl Med	2025
P2RX7 modulates the function of human microglia-like cells and mediates the asso [PMID:40987420]	Heavener KS, Tamucci KA, Lee AJ, Kabra K	Neurobiol Dis	2025
P2RX7 Dynamics in CNS Disorders: Molecular Insights and Therapeutic Perspectives [PMID:41261310]	Mithaiwala A, Thakur J, Godad A	Mol Neurobiol	2025
Higher immune-related gene expression in major depression is independent of CRP [PMID:37264010]	Sforzini L, Cattaneo A, Ferrari C, Turne	Transl Psychiatry	2023
Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhanc [PMID:32049051]	Zhou Y, Fei M, Zhang G, Liang WC, Lin W	Immunity	2020
P2X7 Receptor as a Therapeutic Target. [PMID:27038372]	De Marchi E, Orioli E, Dal Ben D, Adinol	Adv Protein Chem Struct Biol	2016

P2RX7

Understanding Entity Pages

Summary

Wiki Pages (21)

P2RX7 Gene

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

coq10-neurodegeneration

Astrocyte Reactivity Mechanism

Pathway Diagram

Outgoing (366)

Incoming (234)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Do P2RX7 antagonists selectively block pathogenic exosomes while preserving bene

Tau propagation mechanisms and therapeutic interception points

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Experiments (1)

Related Papers (10)

P2RX7

Understanding Entity Pages

Summary

Wiki Pages (21)

P2RX7 Gene

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

coq10-neurodegeneration

Astrocyte Reactivity Mechanism

omega-3-fatty-acids-neurodegeneration

Sulforaphane and Nrf2 Activation for Neuroprotection

Coenzyme Q10 for Neurodegeneration

deferiprone-neurodegeneration

Section 152: Advanced Robotics and Assistive Devices in CBS/PSP

Section 147: Telehealth and Remote Monitoring in CBS/PSP

vitamin-d-therapy-neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Mediterranean and MIND Diets for Neurodegeneration

creatine-supplementation-neurodegeneration

Section 233: Advanced Virtual Reality and Immersive Technology-Based Rehabilitation in CBS/PSP

Ambroxol for Neurodegeneration (GCase Chaperone Strategy)

NAD+ Precursors for Neurodegeneration

O-GlcNAcase (OGA) Inhibitor Landscape — Programs, Mechanisms, Companies

Pathway Diagram

Outgoing (366)

Incoming (234)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Do P2RX7 antagonists selectively block pathogenic exosomes while preserving bene

Tau propagation mechanisms and therapeutic interception points

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Experiments (1)

Related Papers (10)