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TFEB silencing and misfolded protein degradation

experiment Created: 2026-04-06 12:29:04 By: experiment_extractor Quality: 88% ✓ SciDEX ID: experiment-exp-2141f24c-6948-4c8b-a156-2
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TFEB
Metadata
experiment_typecell_biology
protocolTFEB silencing using siRNA followed by trehalose treatment and measurement of misfolded protein levels using filter retardation assay and immunoblotting
expected_outcomesTFEB silencing should counteract trehalose's ability to promote misfolded protein degradation
success_criteriaSignificant reduction in trehalose's pro-degradative activity when TFEB is silenced
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:29:04.356059
source_pmid30335591
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:29:04.396079'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (40)
derives_from📄Trehalose induces autophagy via lysosomal-mediated TFEB acti100%
related🧫Trehalose-induced lysosomal changes and TFEB activation100%
related🧫Trehalose analog testing for autophagy induction100%
related🧫Trehalose-induced lysosomal membrane permeabilization and TF100%
related🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction100%
related🧪TFEB-PGC1α Mitochondrial-Lysosomal Decoupling100%
mentions📖entities-tfeb80%
mentions📖TFEB80%
mentions📖TFEB-Mediated Lysosomal Biogenesis80%
mentions📖TFEB Activators for Parkinson's Disease80%
mentions📖TFEB Protein (Transcription Factor EB)80%
mentions📖TFEB Protein80%
mentions📖TFEB Activators in Neurodegeneration80%
mentions📖tfeb-activators-neurodegeneration80%
related📖entities-tfeb72%
related📖TFEB72%
related📖TFEB-Mediated Lysosomal Biogenesis72%
related📖TFEB Activators for Parkinson's Disease72%
related📖TFEB Protein (Transcription Factor EB)72%
related📖TFEB Protein72%
related📖TFEB Activators in Neurodegeneration72%
related📖tfeb-activators-neurodegeneration72%
mentions📖TFEB Autophagy Pathway70%
mentions📖TFEB Signaling in Neurodegeneration70%
mentions📖TFEB Activator Therapies for Neurodegenerative Diseases70%
related📖TFEB Autophagy Pathway63%
related📖TFEB Signaling in Neurodegeneration63%
related📖TFEB Activator Therapies for Neurodegenerative Diseases63%
mentions📖diseases60%
mentions📖researchers60%
related🧫Transcriptome sequencing of cardiac fibroblasts in TFEB over60%
related🧫Functional validation of trehalose effects on misfolded prot60%
related🧫Trehalose-induced lysosomal changes and TFEB activation60%
related🧫Trehalose analog testing for autophagy induction60%
related🧫Trehalose-induced lysosomal membrane permeabilization and TF60%
related🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction60%
related🧪TFEB-PGC1α Mitochondrial-Lysosomal Decoupling60%
related📖autophagy55%
related📖diseases54%
related📖researchers54%

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