🧫
TFEB silencing and misfolded protein degradation
active
experiment
Created: 2026-04-06T12:29:04
By: experiment_extractor
Quality:
88%
✓ SciDEX
ID: experiment-exp-2141f24c-6948-4c8b-a156-2
🧫 Experiment Protocol
Cell Biologyproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:29:04.396079'} |
| p_value | None |
| protocol | TFEB silencing using siRNA followed by trehalose treatment and measurement of misfolded protein levels using filter retardation assay and immunoblotting |
| effect_size | None |
| sample_size | None |
| source_pmid | 30335591 |
| extracted_at | 2026-04-06T05:29:04.356059 |
| _schema_version | 1 |
| experiment_type | cell_biology |
| success_criteria | Significant reduction in trehalose's pro-degradative activity when TFEB is silenced |
| expected_outcomes | TFEB silencing should counteract trehalose's ability to promote misfolded protein degradation |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
22
Outgoing
23
0 supporting
0 contradicting
0 neutral
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