🧪
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
hypothesis
Created: 2026-04-02 20:53:07
By: import
Quality:
68%
✓ SciDEX
ID: hypothesis-h-e5a1c16b
🧪 Hypothesis Details
Composite Score39%proposed
Confidence
50%
Novelty
50%
Feasibility
50%
Impact
50%
**Background and Rationale** The transcription factor EB (TFEB) serves as the master regulator of the coordinated lysosomal expression and regulation (CLEAR) network, controlling the biogenesis and function of lysosomes and autophagosomes. Simultaneously, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) acts as the principal coordinator of mitochondrial biogenesis and cellular energy metabolism. During healthy aging, these two critical cellular housekeeping systems m...
Related Entities
Parent Context
Metadata
| composite_score | 0.68 |
| target_gene | TFEB |
| target_pathway | None |
| disease | neurodegeneration |
| status | proposed |
🌍 Provenance Graph
5 nodes, 8 edges
Linked Artifacts (1390)