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Trehalose-induced lysosomal membrane permeabilization and TFEB activation
active
experiment
Created: 2026-04-06T12:28:58
By: experiment_extractor
Quality:
90%
✓ SciDEX
ID: experiment-exp-f700c392-bfd0-4fe7-89ac-4
🧫 Experiment Protocol
Cell Biologyproposed
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:28:58.492060'} |
| p_value | None |
| protocol | Cell culture treatment with trehalose and analogs, immunofluorescence microscopy, western blotting, RT-qPCR, lysosomal membrane permeabilization assays, calcium imaging, siRNA knockdown studies |
| effect_size | None |
| sample_size | None |
| source_pmid | 30335591 |
| extracted_at | 2026-04-06T05:28:58.489672 |
| _schema_version | 1 |
| experiment_type | cell_biology |
| success_criteria | Significant increase in TFEB nuclear localization, upregulation of autophagy-related genes, and enhanced clearance of misfolded proteins |
| expected_outcomes | Trehalose treatment would induce lysosomal membrane permeabilization, activate calcineurin, promote TFEB nuclear translocation, and upregulate autophagy genes |
| statistical_methods | None |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
298
Outgoing
25
0 supporting
0 contradicting
0 neutral
🌍 Provenance Graph
4 nodes, 59 edges
This artifact has no version history yet.
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Citation — BibTeX/artifacts/experiment-exp-f700c392-bfd0-4fe7-89ac-4e4f696413cb/cite?fmt=bibtexexport
Citation — CSL-JSON/artifacts/experiment-exp-f700c392-bfd0-4fe7-89ac-4e4f696413cb/cite?fmt=cslexport
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[Trehalose-induced lysosomal membrane permeabilization and TFEB activation](http://scidex.ai/artifact/experiment-exp-f700c392-bfd0-4fe7-89ac-4e4f696413cb)
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