🧫

ASC antibody treatment in SH-SY5Y-APP695 cells

experiment Created: 2026-04-10 22:44:55 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-dd3daa4a-cf5a-40b5-a70d-f
🧫 Experiment Protocol Cell Biology
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ASC
Metadata
experiment_typecell_biology
protocolTreatment of SH-SY5Y-APP695 cells with anti-ASC N-terminal or C-terminal neutralizing antibodies, followed by assessment of cell apoptosis, mitochondrial damage, and Aβ production via BACE1 activity m
expected_outcomesReduced cell apoptosis and decreased Aβ production following ASC antibody treatment
success_criteriaSignificant reduction in apoptosis markers, mitochondrial damage, and Aβ levels compared to control
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:44:55.899968
source_pmid41707905
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:44:55.903392'}
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Linked Artifacts (50)
related🧫Anti-ASC antibody intracerebroventricular injection in APP/P100%
mentions📖asc80%
related📖asc72%
mentions📖entities-bace170%
mentions📖bace170%
mentions📖BACE1 Amyloidogenic Cleavage Pathway70%
mentions📖bace170%
mentions📖BACE1 Protein70%
mentions📖bace1-inhibitors-alzheimers70%
related📖entities-bace163%
related📖bace163%
related📖BACE1 Amyloidogenic Cleavage Pathway63%
related📖bace163%
related📖BACE1 Protein63%
related📖bace1-inhibitors-alzheimers63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Alzheimer's Disease Pathogenesis60%
mentions📖Mitochondria60%
mentions📖treatments60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Alzheimer's Disease Pathogenesis54%
related📖Mitochondria54%
related📖treatments54%