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entity_type	gene
kg_node_id	ASC

Linked Artifacts (314)

mentions🧫Anti-ASC antibody intracerebroventricular injection in APP/P80%

mentions🧫ASC antibody treatment in SH-SY5Y-APP695 cells80%

mentions🔬What are the mechanisms underlying perivascular spaces and g75%

see_also📖Cell-Free DNA Biomarkers in Neurodegeneration75%

see_also📖Exosomal Biomarkers in Neurodegeneration75%

see_also📖Exosomal miR-155 in Neurodegeneration75%

see_also📖IL-6 (Interleukin-6) in Neurodegeneration75%

see_also📖Liquid Biopsy in Neurodegeneration75%

see_also📖Metabolomic Biomarkers in Neurodegeneration75%

see_also📖Neuroimaging Biomarkers for Neurodegeneration75%

see_also📖Synaptic Biomarkers in Neurodegeneration75%

see_also📖BEACoN Study - Biomarker Exploration in Aging, Cognition and75%

see_also📖Olfactory Mucosa, Blood and Urine for Identification of Earl75%

see_also📖Swedish BioFINDER 2 Study: Biomarkers and Neurodegeneration 75%

see_also📖Beta-Propeller Protein-Associated Neurodegeneration (BPAN)75%

see_also📖China Neurodegeneration Epidemiology75%

see_also📖DALY Methodology — Neurodegeneration75%

see_also📖Disease Progression & Staging in Neurodegeneration75%

see_also📖Economic Burden — Neurodegeneration75%

see_also📖European Neurodegeneration Epidemiology75%

see_also📖Familial vs Sporadic Neurodegeneration Comparison75%

see_also📖Global Neurodegeneration Epidemiology75%

see_also📖India Neurodegeneration Epidemiology75%

see_also📖Japan Neurodegeneration Epidemiology75%

see_also📖Manganese-Related Neurodegeneration (Manganism)75%

see_also📖mitochondrial-dysfunction-neurodegeneration-comparison75%

see_also📖Mitochondrial Diseases and Neurodegeneration Comparison Matr75%

see_also📖Mitochondrial Membrane Protein-Associated Neurodegeneration 75%

see_also📖Neurodegeneration with Brain Iron Accumulation (NBIA)75%

see_also📖Potential Impact Measures — Neurodegeneration75%

see_also📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)75%

see_also📖PLA2G6-Associated Neurodegeneration (PLAN)75%

see_also📖Sleep Disorders in Neurodegeneration75%

see_also📖US Neurodegeneration Epidemiology75%

see_also📖Extracellular Vesicle and Tunneling Nanotube-Mediated Spread75%

see_also📖acetylcholine-signaling-neurodegeneration75%

see_also📖Advanced Glycation End Products in Neurodegeneration75%

see_also📖Advanced In Vitro Models for Neurodegeneration — Organoids, 75%

see_also📖Amylin Signaling in Neurodegeneration75%

see_also📖Antibody Therapy in Neurodegeneration75%

see_also📖Antisense Oligonucleotide (ASO) Therapy in Neurodegeneration75%

see_also📖Autosis Pathway in Neurodegeneration75%

see_also📖Axon Guidance Pathways in Neurodegeneration75%

see_also📖Basal Ganglia Circuit Dysfunction in Neurodegeneration75%

see_also📖becn1-autophagy-initiation-neurodegeneration-causal-chain75%

see_also📖CaMKII Signaling Pathway in Neurodegeneration75%

see_also📖Carbonic Anhydrase Modulator Therapy in Neurodegeneration75%

see_also📖Cerebral Amyloid Angiopathy in Neurodegeneration75%

see_also📖Cerebral Amyloid Angiopathy Pathway in Neurodegeneration75%

see_also📖Cholinergic System Dysfunction in Neurodegeneration75%

see_also📖Chrononutrition and Time-Restricted Eating in Neurodegenerat75%

see_also📖Neural Circuits in Neurodegeneration75%

see_also📖Cognitive Reserve and Resilience in Neurodegeneration75%

see_also📖Computational Disease Models for Neurodegeneration75%

see_also📖Convergent Pathways in Neurodegeneration75%

see_also📖Copper Homeostasis in Neurodegeneration75%

see_also📖COVID-19 Neurodegeneration Mechanism75%

see_also📖Diffusion MRI (DTI) in Neurodegeneration75%

see_also📖Digital Phenotyping in Neurodegeneration75%

see_also📖Down Syndrome Neurodegeneration Pathway75%

see_also📖Dystrophic Neurites in Neurodegeneration75%

see_also📖Endocannabinoid System in Neurodegeneration75%

see_also📖Endosomal-Lysosomal Pathway in Neurodegeneration75%

see_also📖Endosomal Sorting Defects in Neurodegeneration75%

see_also📖Endothelin Signaling Pathway in Neurodegeneration75%

see_also📖epigenetics-neurodegeneration75%

see_also📖ESCRT-III Inhibition by Alpha-Synuclein in Neurodegeneration75%

see_also📖FA2H-Associated Neurodegeneration Pathway75%

see_also📖Farnesoid X Receptor (FXR) Signaling in Neurodegeneration75%

see_also📖Galectin-3 Mechanism in Neurodegeneration75%

see_also📖Gangliosides in Neurodegeneration75%

see_also📖GDF15/GDF11 Signaling in Neurodegeneration75%

see_also📖GDNF Signaling Pathway in Neurodegeneration75%

see_also📖Ghrelin Signaling Pathway in Neurodegeneration75%

see_also📖Glucocorticoid Signaling Pathway in Neurodegeneration75%

see_also📖Glycosylation in Neurodegeneration75%

see_also📖gp130/IL-6 Family Cytokine Signaling in Neurodegeneration75%

see_also📖Hippocampal Neurogenesis in Neurodegeneration75%

see_also📖Histone Modification Pathways in Neurodegeneration75%

see_also📖HMGB1 Signaling in Neurodegeneration75%

see_also📖Homocysteine Neurotoxicity and Neurodegeneration75%

see_also📖IGF-1 Signaling Pathway in Neurodegeneration75%

see_also📖IL-1 Signaling Pathway in Neurodegeneration75%

see_also📖Integrated Stress Response in Neurodegeneration75%

see_also📖interleukin-6-signaling-neurodegeneration75%

see_also📖Intrinsic Apoptosis Pathway in Neurodegeneration75%

see_also📖Ion Channel Dysfunction in Neurodegeneration: Cross-Disease 75%

see_also📖Kidney-Brain Neurodegeneration Axis75%

see_also📖Lipid Dysregulation in Neurodegeneration75%

see_also📖Lipid Metabolism Dysregulation in Neurodegeneration75%

see_also📖Lysosomal Calcium Dysregulation in Neurodegeneration75%

see_also📖Magnetic Resonance Spectroscopy in Neurodegeneration75%

see_also📖Metal Homeostasis Dysregulation in Neurodegeneration75%

see_also📖Metal Homeostasis in Neurodegeneration75%

see_also📖Microglial Priming Pathway in Neurodegeneration75%

see_also📖MicroRNA Dysfunction in Neurodegeneration75%

see_also📖Mineralocorticoid Receptor Signaling in Neurodegeneration75%

see_also📖Mitochondrial Dynamics Pathway in Neurodegeneration75%

see_also📖Mitochondrial Fusion in Neurodegeneration75%

see_also📖Molecular Chaperones in Neurodegeneration75%

see_also📖mTOR Signaling in Neurodegeneration75%

see_also📖mTOR Signaling Pathway in Neurodegeneration75%

see_also📖Neural Circuit Disruption in Neurodegeneration75%

see_also📖Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in N75%

see_also📖Neurofilament Light Chain (NfL) Mechanism in Neurodegenerati75%

see_also📖Neuronal Hyperexcitability in Neurodegeneration75%

see_also📖Neuropil Threads in Neurodegeneration75%

see_also📖Neurotensin Signaling in Neurodegeneration75%

see_also📖Neurovascular Unit Dysfunction in Neurodegeneration75%

see_also📖NF-kB Signaling Pathway in Neurodegeneration75%

see_also📖Nitric Oxide Signaling in Neurodegeneration75%

see_also📖Noradrenergic Signaling Pathway in Neurodegeneration75%

see_also📖Neuropeptide Y Signaling in Neurodegeneration75%

see_also📖NRF2 Signaling Pathway in Neurodegeneration75%

see_also📖Nuclear Pore Complex Dysfunction in Neurodegeneration75%

see_also📖Orexin Signaling in Neurodegeneration75%

see_also📖OSK Reprogramming and Yamanaka Factors in Neurodegeneration75%

see_also📖P-Body (Processing Body) Pathway in Neurodegeneration75%

see_also📖Paranodal Dysfunction in Neurodegeneration75%

see_also📖Paraptosis in Neurodegeneration75%

see_also📖Parthanatos in Neurodegeneration75%

see_also📖Pericyte Loss in Neurodegeneration75%

see_also📖Peripheral Immune-Brain Crosstalk in Neurodegeneration75%

see_also📖PKR Pathway in Neurodegeneration75%

see_also📖PPAR Signaling Pathway in Neurodegeneration75%

see_also📖Prion Diseases in Neurodegeneration75%

see_also📖Prion-Like Spread in Neurodegeneration75%

see_also📖Prion Protein Metabolism in Neurodegeneration75%

see_also📖Progesterone Signaling Pathway in Neurodegeneration75%

see_also📖Prognostic Biomarkers in Neurodegeneration75%

see_also📖Protein Aggregation Comparison in Neurodegeneration75%

see_also📖Protein Aggregation Seeds in Neurodegeneration75%

see_also📖Protein O-GlcNAcylation Pathway in Neurodegeneration75%

see_also📖Cortical Involvement and Neurodegeneration in Progressive Su75%

see_also📖Purinergic Signaling in Neurodegeneration75%

see_also📖Quantum Biology and Coherent Energy Transfer in Neurodegener75%

see_also📖R-Loop Stress in Neurodegeneration75%

see_also📖RAN Translation in Neurodegeneration75%

see_also📖Retinal Degeneration Pathway in Neurodegeneration75%

see_also📖Ribosome Dysfunction in Neurodegeneration75%

see_also📖RNA Splicing in Neurodegeneration75%

see_also📖RNA-Targeted Therapies in Neurodegeneration75%

see_also📖Ribonuclease κ and Circular RNAs: A New Mechanism of Aging a75%

see_also📖S100 Protein Signaling Pathway in Neurodegeneration75%

see_also📖Senescent Cell Clearance in Neurodegeneration75%

see_also📖Serotonergic Dysfunction in Neurodegeneration75%

see_also📖Sex Differences in Neurodegeneration75%

see_also📖Short Chain Fatty Acids in Neurodegeneration75%

see_also📖Sigma-1 Receptor Signaling in Neurodegeneration75%

see_also📖Sirtuin-Mitochondrial Biogenesis Axis in Neurodegeneration75%

see_also📖Sleep Dysfunction in Neurodegeneration75%

see_also📖SUMOylation in Neurodegeneration75%

see_also📖synaptic-vesicle-cycling-neurodegeneration75%

see_also📖Synthetic Lethality and PARP Inhibition in Neurodegeneration75%

see_also📖T-Cell Dysfunction in Neurodegeneration75%

see_also📖Tertiary Lymphoid Organs in Neurodegeneration75%

see_also📖Therapeutic Targets in Neurodegeneration75%

see_also📖Transdiagnostic Proteomic Changes in Neurodegeneration75%

see_also📖ubiquitin-proteasome-dysfunction-neurodegeneration75%

see_also📖Ubiquitin-Proteasome System Dysfunction in Neurodegeneration75%

see_also📖Vagus Nerve Pathway in Neurodegeneration75%

see_also📖VEGF Signaling and Cerebral Angiogenesis in Neurodegeneratio75%

see_also📖vip-vasoactive-intestinal-peptide-signaling-neurodegeneratio75%

see_also📖WNK1-Bilirubin Signaling in Neuroinflammation and Neurodegen75%

see_also📖Wnt/β-Catenin Signaling Pathway in Neurodegeneration75%

related🧫Anti-ASC antibody intracerebroventricular injection in APP/P72%

related🧫ASC antibody treatment in SH-SY5Y-APP695 cells72%

mentions🧫NLRP3 Inflammasome Validation Study in Parkinson's Dise70%

mentions🧪Circadian-Synchronized LRP1 Pathway Activation70%

mentions🧪Synthetic Biology BBB Endothelial Cell Reprogramming70%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%

mentions🧪Selective HDAC3 Inhibition with Cognitive Enhancement70%

mentions🧪Complement C1q Mimetic Decoy Therapy70%

mentions🧪Age-Dependent Complement C4b Upregulation Drives Synaptic Vu70%

mentions🧪Retinal Vascular Microcirculation Rescue70%

mentions🧪Complement C1q Subtype Switching70%

mentions🧪HDAC3-Selective Inhibition for Clock Reset70%

mentions🧪Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat70%

mentions🧪Complement C1QA Spatial Gradient in Cortical Layers70%

see_also📖Tau Kinase Signaling Cascade in Alzheimer's Disease65%

related🧫NLRP3 Inflammasome Validation Study in Parkinson's Dise63%

related🧪Circadian-Synchronized LRP1 Pathway Activation63%

related🧪Synthetic Biology BBB Endothelial Cell Reprogramming63%

related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%

related🧪Selective HDAC3 Inhibition with Cognitive Enhancement63%

related🧪Complement C1q Mimetic Decoy Therapy63%

related🧪Age-Dependent Complement C4b Upregulation Drives Synaptic Vu63%

related🧪Retinal Vascular Microcirculation Rescue63%

related🧪Complement C1q Subtype Switching63%

related🧪HDAC3-Selective Inhibition for Clock Reset63%

related🧪Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat63%

related🧪Complement C1QA Spatial Gradient in Cortical Layers63%

mentions🔬Comprehensive analysis of immune cell subtypes in neurodegen60%

see_also📖ACTB Gene60%

see_also📖aim260%

see_also📖ALDH1L160%

see_also📖ATF6 - Activating Transcription Factor 660%

see_also📖ATG14 Gene60%

see_also📖CBL Gene60%

see_also📖DDX6 Gene60%

see_also📖MARCH7 — Membrane Associated Ring-CH Type Finger 760%

see_also📖NOD2 Gene60%

see_also📖Purinergic Receptor P2X 7 (P2X7)60%

see_also📖slc1a3 Gene60%

see_also📖SYK Gene60%

see_also📖SYN1 Gene60%

see_also📖TAK1 Gene60%

see_also📖ZDHHC12 (Zinc Finger DHHC-Type Containing 12)60%

see_also📖AIM2 Inflammasome Modulation Therapy for Neurodegeneration60%

see_also📖Alzheimer Indonesia60%

see_also📖AIM2 Protein60%

see_also📖proteins-atf660%

see_also📖ATG14 Protein60%

see_also📖Interleukin-18 Protein60%

see_also📖p2x760%

see_also📖atp6v0d160%

see_also📖BRG1 Gene60%

see_also📖CASP1 Gene60%

see_also📖csf160%

see_also📖IL18 Gene60%

see_also📖LIMK1 Gene60%

see_also📖MELK Gene60%

see_also📖MYD88 Gene60%

see_also📖NEK7 Gene60%

see_also📖NLRC4 Gene60%

see_also📖PAK1 Gene60%

see_also📖RAC1 Gene60%

see_also📖ripk260%

see_also📖SMARCA460%

see_also📖TIRAP — TIR Domain-Containing Adaptor Protein60%

see_also📖TNF Gene60%

see_also📖TOMM20 — Translocase of Outer Mitochondrial Membrane 2060%

see_also📖TRAF6 Gene60%

see_also📖VAMP8 — Vesicle Associated Membrane Protein 860%

see_also📖LIM Kinase 1 (LIMK1)60%

see_also📖FIS1 Gene60%

see_also📖Packard Center for ALS Research60%

see_also📖JAK1 — Janus Kinase 160%

see_also📖NLRP1 Gene60%

see_also📖NLRP2 — NLR Family Pyrin Domain Containing 260%

see_also📖NQO1 — NAD(P)H Quinone Dehydrogenase 160%

see_also📖PCBP1 Gene60%

see_also📖SLC40A1 Gene60%

see_also📖STAT1 Gene - Signal Transducer and Activator of Transcriptio60%

see_also📖STAT4 Gene60%

see_also📖txnip60%

see_also📖NQO1 Protein (NAD(P)H Quinone Dehydrogenase 1)60%

see_also📖AMPK (AMP-Activated Protein Kinase)60%

see_also📖AIF1 Gene60%

see_also📖UCP2 — Uncoupling Protein 260%

see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%

see_also📖Uncoupling Protein 2 (UCP2)60%

see_also📖AIF Gene60%

see_also📖TRAF360%

mentions🔬What are the mechanisms underlying 4r-tau strain-specific sp50%

mentions🔬What are the mechanisms underlying what are the mechanisms b50%

mentions🧫NLRP3 Inflammasome Validation Study in Parkinson's Dise50%

mentions🧪Microglial Purinergic Reprogramming50%

mentions🧪Microbial Inflammasome Priming Prevention50%

mentions🧪Glymphatic System-Enhanced Antibody Clearance Reversal50%

mentions🧪SASP-Driven Aquaporin-4 Dysregulation50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

mentions🧪Lysosomal Positioning Dynamics Modulation50%

mentions🧪Autophagosome Maturation Checkpoint Control50%

mentions🧪Optogenetic Microglial Deactivation via Engineered Inhibitor50%

mentions🧪Fractalkine Axis Amplification via CX3CR1 Positive Allosteri50%

mentions🧪LRP1-Dependent Tau Uptake Disruption50%

related🧪APOE-Dependent Autophagy Restoration50%

related🧪Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam50%

related🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%

related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%

related🔬What are the mechanisms underlying what are the mechanisms b50%

related🔬What are the mechanisms underlying perivascular spaces and g50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬Comprehensive analysis of immune cell subtypes in neurodegen50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%

related🔬What are the mechanisms underlying synaptic pruning by micro50%

related🔬Epigenetic reprogramming in aging neurons50%

see_also📖KarXT for Alzheimer's Disease Cognitive Impairment - MI50%

see_also📖A Phase 3, Randomised, Double-blinded, Placebo-controlled St50%

see_also📖Novartis Alzheimer's Disease Phase 2 Trial (NCT0709451650%

see_also📖Rotigotine and Rivastigmine Combination Therapy for Alzheime50%

see_also🧪APOE-Dependent Autophagy Restoration50%

see_also🧪Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam50%

see_also🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%

see_also📖LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE45%

see_also📖APOE4 (Apolipoprotein E4)45%

see_also📖Cross-National Cancer-Dementia Correlation and Shared Diseas45%

see_also📖Cancer-Dementia Inverse Correlation: Epidemiological Evidenc45%

see_also📖SNCA — Alpha-Synuclein Gene Entity Page45%

see_also📖Alzheimer's Disease Mechanism Index45%

see_also📖NLRP3 Inflammasome Inhibitors for Parkinson's Disease45%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Netrin-1 Gradient Restoration40%

related🧪Enteric Nervous System Prion-Like Propagation Blockade40%

related🧪Complement C1q Subtype Switching40%

related🧪Microglial Purinergic Reprogramming40%

related🧪Sphingolipid Metabolism Reprogramming40%

related🧪Gut Barrier Permeability-α-Synuclein Axis Modulation40%

related🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation40%

related🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis40%

related🧪Glial Glycocalyx Remodeling Therapy40%

related🧪Aquaporin-4 Polarization Rescue40%

related🧪Ephrin-B2/EphB4 Axis Manipulation40%

related🧪Microbial Inflammasome Priming Prevention40%

related🧪Vagal Afferent Microbial Signal Modulation40%

related🧪Microbiome-Derived Tryptophan Metabolite Neuroprotection40%

related🔬PSP and CBD both involve 4R-tau but produce distinct neuropa40%

related🔬What are the mechanisms underlying what are the mechanisms b40%

related🔬What are the mechanisms underlying 4r-tau strain-specific sp24%