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bace1

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slug	proteins-bace1
entity_type	protein
kg_node_id	BACE1

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mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors90%

mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors80%

related🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors80%

mentions🔬Investigate how lipid raft composition (cholesterol metaboli70%

mentions🧫ASC antibody treatment in SH-SY5Y-APP695 cells70%

mentions🧫Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated 70%

mentions🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%

mentions🧫Neural Stem Cell Therapy for Alzheimer's Disease70%

mentions🧫Experiment Validation: In vitro ThT Assay70%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer70%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction70%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy70%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%

mentions🧪Competitive APOE4 Domain Stabilization Peptides70%

related🔬Investigate how lipid raft composition (cholesterol metaboli70%

see_also🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors70%

mentions🧪Multi-Modal Stress Response Harmonization65%

mentions🧪Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu65%

mentions🧪CYP46A1 Overexpression Gene Therapy65%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones65%

mentions🧪Membrane Cholesterol Gradient Modulators65%

mentions🧪Selective Acid Sphingomyelinase Modulation Therapy65%

mentions🧪Sphingomyelin Synthase Activators for Raft Remodeling65%

mentions🧪Excitatory Neuron Vulnerability via SLC17A7 Downregulation65%

mentions🔬Investigate how lipid raft composition (cholesterol metaboli63%

related🧫ASC antibody treatment in SH-SY5Y-APP695 cells63%

related🧫Experimental: CAAR-T Cell Therapy for Autoantibody-Mediated 63%

related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De63%

related🧫Neural Stem Cell Therapy for Alzheimer's Disease63%

related🧫Experiment Validation: In vitro ThT Assay63%

related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer63%

related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction63%

related🧪Targeted APOE4-to-APOE3 Base Editing Therapy63%

related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%

related🧪Competitive APOE4 Domain Stabilization Peptides63%

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see_also📖Lipid Metabolism Dysregulation in Neurodegeneration60%

see_also📖Lysosomal Calcium Dysregulation in Neurodegeneration60%

see_also📖Magnetic Resonance Spectroscopy in Neurodegeneration60%

see_also📖Metal Homeostasis Dysregulation in Neurodegeneration60%

see_also📖Metal Homeostasis in Neurodegeneration60%

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see_also📖MicroRNA Dysfunction in Neurodegeneration60%

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see_also📖Mitochondrial Dynamics Pathway in Neurodegeneration60%

see_also📖Mitochondrial Fusion in Neurodegeneration60%

see_also📖Molecular Chaperones in Neurodegeneration60%

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see_also📖Neuropil Threads in Neurodegeneration60%

see_also📖Neurotensin Signaling in Neurodegeneration60%

see_also📖Neurovascular Unit Dysfunction in Neurodegeneration60%

see_also📖NF-kB Signaling Pathway in Neurodegeneration60%

see_also📖Nitric Oxide Signaling in Neurodegeneration60%

see_also📖Noradrenergic Signaling Pathway in Neurodegeneration60%

see_also📖Neuropeptide Y Signaling in Neurodegeneration60%

see_also📖NRF2 Signaling Pathway in Neurodegeneration60%

see_also📖Nuclear Pore Complex Dysfunction in Neurodegeneration60%

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see_also📖Paraptosis in Neurodegeneration60%

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see_also📖Pericyte Loss in Neurodegeneration60%

see_also📖Peripheral Immune-Brain Crosstalk in Neurodegeneration60%

see_also📖PKR Pathway in Neurodegeneration60%

see_also📖PPAR Signaling Pathway in Neurodegeneration60%

see_also📖Prion Diseases in Neurodegeneration60%

see_also📖Prion-Like Spread in Neurodegeneration60%

see_also📖Prion Protein Metabolism in Neurodegeneration60%

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see_also📖ubiquitin-proteasome-dysfunction-neurodegeneration60%

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see_also📖Wnt/β-Catenin Signaling Pathway in Neurodegeneration60%

see_also📖ABCA7 (Redirect)60%

see_also📖ABCA1 - ATP-Binding Cassette Transporter A160%

see_also📖adam1060%

see_also📖ACE Gene60%

related🧪Multi-Modal Stress Response Harmonization58%

related🧪Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu58%

related🧪CYP46A1 Overexpression Gene Therapy58%

related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones58%

related🧪Membrane Cholesterol Gradient Modulators58%

related🧪Selective Acid Sphingomyelinase Modulation Therapy58%

related🧪Sphingomyelin Synthase Activators for Raft Remodeling58%

related🧪Excitatory Neuron Vulnerability via SLC17A7 Downregulation58%

see_also📖LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE55%

see_also📖LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy for 55%

see_also📖nct0550878955%

see_also📖ALA-enriched Nutrition for APOE4 Carriers with MCI (NCT0739255%

see_also📖remternetug-anti-amyloid-alzheimers55%

see_also📖UPenn Observational Research Repository (NCT04715399)55%

see_also📖APOE2 (Apolipoprotein E2)55%

see_also📖APOE3 (Apolipoprotein E3)55%

see_also📖APOE4 (Apolipoprotein E4)55%

mentions🧪SASP-Mediated Cholinergic Synapse Disruption50%

mentions🧪Biorhythmic Interference via Controlled Sleep Oscillations50%

mentions🧪LRP1-Dependent Tau Uptake Disruption50%

mentions🧪APOE-Mediated Synaptic Lipid Raft Stabilization50%

mentions🧪Circadian-Synchronized LRP1 Pathway Activation50%

mentions🧪Blood-Brain Barrier SPM Shuttle System50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪Osmotic Gradient Restoration via Selective AQP1 Enhancement 50%

mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

mentions🧪Circadian Rhythm Entrainment of Reactive Astrocytes50%

mentions🧪Temporal Decoupling via Circadian Clock Reset50%

mentions🧪Circadian Clock-Autophagy Synchronization50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

mentions🧪Perforant Path Presynaptic Terminal Protection Strategy50%

mentions🧪Nutrient-Sensing Epigenetic Circuit Reactivation50%

mentions🧪Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration50%

mentions🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪APOE Isoform Conversion Therapy50%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

mentions🧪Epigenetic Memory Reprogramming for Alzheimer's Disease50%

mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%

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mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

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related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer40%

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related🧪SASP-Mediated Cholinergic Synapse Disruption40%

related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m40%

related🧪Biorhythmic Interference via Controlled Sleep Oscillations40%

related🧪LRP1-Dependent Tau Uptake Disruption40%

related🧪Circadian-Synchronized LRP1 Pathway Activation40%

related🧪Blood-Brain Barrier SPM Shuttle System40%

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related🔬APOE4 differs from APOE3 by C112R causing domain interaction40%

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mentions🔬What are the mechanisms underlying microglia-astrocyte cross35%

mentions🔬What are the mechanisms underlying apoe4 structural biology 35%

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