gene

ASC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ASC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

948Connections

15Hypotheses

18Analyses

50Outgoing

50Incoming

Summary

ASC is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, activates. Associated with ALS, Aging, Als. Connected to 255 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	ASC
Full Name	asc
Chromosome	16p11.2
Protein Type	Gene
Function	is a 195-amino acid adaptor protein that serves as a central node in innate immune signaling.
Primary Expression	microglia, astrocytes, and certain neurons, where it drives neuroinflammation and contributes to the pathogenesis of Alzheimer's disease, Parkinson's
Molecular Weight	22 kDa
Pathways	Apoptosis, Inflammasome, Innate Immunity, Pyroptosis
UniProt ID	Q9Y258
NCBI Gene ID	29108
GeneCards	ASC
Human Protein Atlas	ASC
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Atherosclerosis
Known Drugs/Compounds	rapamycin
Interactions	GAPDH, AIF1, GFAP, ACTB, NLRP3, ZDHHC12
KG Connections	948 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ASC — AlphaFold Q9Y258 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ASC["ASC"] -.->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    ASC["ASC"] -.->|"inhibits"| Inflammation["Inflammation"]
    ASC["ASC"] -.->|"inhibits"| Als["Als"]
    ASC["ASC"] -.->|"inhibits"| Aging["Aging"]
    ASC["ASC"] -->|"regulates"| Tumor["Tumor"]
    ASC["ASC"] -->|"regulates"| Parkinson["Parkinson"]
    NLRP3["NLRP3"] -->|"activates"| ASC["ASC"]
    ACTB["ACTB"] -.->|"inhibits"| ASC["ASC"]
    IL1B["IL1B"] -->|"regulates"| ASC["ASC"]
    IL6["IL6"] -->|"regulates"| ASC["ASC"]
    style ASC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (709)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Inflammasome	activates	pathway	1.00
INFLAMMATION	activates	gene	1.00
NLRP3	interacts_with	entity	0.90
MICROGLIA	expressed_in	cell_type	0.90
ASTROCYTES	expressed_in	cell_type	0.90
oxidative stress response	participates_in	pathway	0.90
pyroptosis	participates_in	pathway	0.90
apoptosis pathway	participates_in	pathway	0.90
microglia	expressed_in	cell_type	0.90
Tumor	associated_with	disease	0.85
Inflammasome	modulates	pathway	0.85
ALZHEIMER'S DISEASE	involved_in	disease	0.85
inflammasome	modulates	biological_process	0.80
Aβ plaques	associated_with	biological_process	0.80
autophagy pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
microglia	associated_with	cell_type	0.80
microglia	activates	cell_type	0.80
autism spectrum disorder	interacts_with	disease	0.80
NLRP3	associated_with	gene	0.80
TNF	associated_with	gene	0.80
PYCARD	associated_with	gene	0.80
Inflammasome	inhibits	pathway	0.80
Autophagy	inhibits	pathway	0.80
Inflammation	inhibits	disease	0.75
Als	inhibits	disease	0.75
Als	activates	disease	0.75
Alzheimer	activates	disease	0.75
AIM2	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
CASP1	associated_with	gene	0.70
IL1B	associated_with	gene	0.70
UBIQUITIN	regulates	gene	0.70
SQSTM1	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
LC3	associated_with	gene	0.70
PYCARD	activates	gene	0.70
substantia nigra	expressed_in	brain_region	0.70
NLRP3	releases	gene	0.70
NLRP3	biomarker_for	gene	0.70
Autophagy	associated_with	pathway	0.70
AUTOPHAGY	inhibits	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
INFLAMMATION	inhibits	gene	0.70
MICROGLIA	activates	gene	0.70
ALZHEIMER	activates	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
Parkinson's disease	regulates	disease	0.70
macrophages	expressed_in	cell_type	0.70

Incoming (239)

Source	Relation	Type	Str
NLRP3	activates	protein	1.00
NLRP3	interacts_with	protein	0.90
TNF	regulates	gene	0.70
NLRP3	regulates	gene	0.70
AUTOPHAGY	inhibits	gene	0.70
rapamycin	targets	drug	0.70
ACTB	inhibits	gene	0.60
IL1B	regulates	gene	0.60
IL6	regulates	gene	0.60
CASP1	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
SNCA	regulates	gene	0.60
BECN1	inhibits	gene	0.60
AIF1	inhibits	gene	0.60
ATG7	inhibits	gene	0.60
IL1B	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
ATG5	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
IL18	associated_with	gene	0.60
SQSTM1	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
GAPDH	inhibits	gene	0.60
PYCARD	regulates	gene	0.60
TNF	associated_with	gene	0.60
MARCH7	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
AIM2	associated_with	gene	0.60
NLRP1	expressed_in	gene	0.60
NLRP2	expressed_in	gene	0.60
UBIQUITIN	regulates	gene	0.60
IBA1	inhibits	gene	0.60
UBIQUITIN	associated_with	gene	0.60
SQSTM1	activates	gene	0.60
SIRT2	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
RIPK2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
CBL	activates	gene	0.60
NOD2	activates	gene	0.60
MARCH7	activates	gene	0.60
ZDHHC12	activates	gene	0.60
AIM2	inhibits	gene	0.60
NLRC4	inhibits	gene	0.60
UCP2	inhibits	gene	0.60

Targeting Hypotheses (15)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Mediated Complement Cascade Amplification	0.703	neurodegeneration	Senolytic therapy for age-related neurod
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.587	neuroinflammation	What molecular mechanisms drive the tran
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.559	neurodegeneration	How does PIKFYVE inhibition activate unc
Senescent Cell ASM-Complement Cascade Intervention	0.552	neurodegeneration	Lipid raft composition changes in synapt
Vascular-Glial Interface Restoration	0.544	neurodegeneration	Cell type vulnerability in Alzheimers Di

Retinal Vascular Microcirculation Rescue	0.542	neurodegeneration	Digital biomarkers and AI-driven early d
TREM2-Mediated Microglial Dysfunction Disrupts Perivascular	0.527	neuroscience	Circuit-level neural dynamics in neurode
Vascular mural cell degeneration precedes and exacerbates pa	0.520	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Dual-Circuit Tau Vulnerability Cascade	0.499	neuroscience	Circuit-level neural dynamics in neurode
Cardiovascular-Neuroinflammatory Dual Targeting	0.462	neurodegeneration	Neuroinflammation and microglial priming
Dual-Circuit Tau Vulnerability Cascade with Glial-Mediated A	0.461	neuroscience	Circuit-level neural dynamics in neurode
Complement Cascade Activation Bridges Microglial OxPC Sensin	0.452	neuroinflammation	What molecular mechanisms enable microgl
Cardiovascular-Neuroinflammation Crosstalk Interruption	0.437	Alzheimer's disease	Neuroinflammation and microglial priming
Glymphatic-Cholinergic Tau Clearance Cascade	0.431	neuroscience	Circuit-level neural dynamics in neurode
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro	0.424	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (18)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887]	Chen TY, Wu N, Sun X	Life (Basel)	2026	1
Pericyte-derived extracellular vesicles improve vascular barrier function in sep [PMID:39940043]	Zhang ZS, Yang A, Luo X, Zhou HN, Liu YY	Stem Cell Res Ther	2025	1
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Irisin promotes fracture healing by improving osteogenesis and angiogenesis. [PMID:36196152]	Kan T, He Z, Du J, Xu M, Cui J, Han X, T	J Orthop Translat	2022	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blocka [PMID:31343989]	Yang H, Lee WS, Kong SJ, Kim CG, Kim JH,	J Clin Invest	2019	1
Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548]	Hong S, Beja-Glasser VF, Nfonoyim BM, Fr	Science	2016	1
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235]	Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn	Pathology international	2026	0
Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors i [PMID:41914021]	Xie M, Feng L, Li R, Li M, Shen L, Zhang	CNS neuroscience & therapeutic	2026	0
Vaccine-induced antibodies can limit Salmonella infection in the absence of comp [PMID:41738756]	Perez-Toledo M, Aksu-Istil K, Marcial-Ju	mBio	2026	0
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436]	Gopalakrishna PK, Che Mohd Nassir CMN, A	Cellular and molecular neurobi	2026	0
Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-C [PMID:41766448]	Taxiarchis A, Pruner I	Current opinion in hematology	2026	0
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026	0
Benzo[a]pyrene promotes gastric cancer progression via activation of the Correa [PMID:41780474]	Tong J, Liu S, Du T, Liu W, Jin Z et al.	Ecotoxicol Environ Saf	2026	0
Plasma pTau 217/β-amyloid 1-42 ratio for enhanced accuracy and reduced uncertain [PMID:41562409]	Benina N, Buitrago L, De Simone FI, Radw	Brain	2026	0
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990]	Keller A	Annual review of physiology	2026	0
Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in h [PMID:40902811]	Wang Y, Zhang Z, Cao L, Huang S, Huang X	J Ethnopharmacol	2026	0
Based on network pharmacology and experiments to investigate the inhibitory effe [PMID:41308710]	Yang X, Xiao JH, Li X, Liu RM, Yuan Q	J Ethnopharmacol	2026	0

ASC

Understanding Entity Pages

Summary

Wiki Pages (21)

ASC (PYCARD)

neuroinflammation

nlrc5-protein

Glia-Neuron Crosstalk in Alzheimer's Disease

Pannexin 1 and P2X7 Receptor Signaling in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Pathway Diagram

Outgoing (709)

Incoming (239)

Targeting Hypotheses (15)

Mentioning Analyses (18)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular effica

What determines the specificity of calcium-dependent PPP3/calcineurin activation

What are the specific molecular mechanisms by which C1Q components drive atheros

What determines P2RY12 receptor expression/activity specifically in VSMCs during

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

How do perivascular cells specifically recognize and respond to amyloid-β to upr

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What is the therapeutic window between tau propagation inhibition and essential

Quantitative proteomics of the aging synapse in early Alzheimer disease

Immune atlas neuroinflammation analysis in neurodegeneration

Immune atlas neuroinflammation analysis in neurodegeneration

Perivascular spaces and glymphatic clearance failure in AD

4R-tau strain-specific spreading patterns in PSP vs CBD

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Perivascular spaces and glymphatic clearance failure in AD

Related Papers (20)

ASC

Understanding Entity Pages

Summary

Wiki Pages (21)

ASC (PYCARD)

neuroinflammation

nlrc5-protein

Glia-Neuron Crosstalk in Alzheimer's Disease

Pannexin 1 and P2X7 Receptor Signaling in Neurodegeneration

Neuroinflammation Across AD, PD, ALS, FTD, and HD

autophagy-lysosomal-alzheimers

Cytochrome c Protein

OTULIN-Tau Regulation Pathway

NLRP3 Inflammasome Activation Pathway in Neurodegeneration

Neuroinflammation in Alzheimer's Disease

Microglia Activation Mechanism

DNA Sensing Pathways in Neurodegeneration

Neuroinflammation Pathway

Neuroinflammation in Alzheimer's Disease

cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease

Neuroinflammation in Neurodegeneration

nlrp3-inflammasome-activated-microglia

Inflammaging in Neurodegeneration

Section 99: Purinergic Signaling and P2X/P2Y Receptors in CBS/PSP

Sirtuin Signaling Pathway

Pathway Diagram

Outgoing (709)

Incoming (239)

Targeting Hypotheses (15)

Mentioning Analyses (18)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

How does SPI1 transcriptionally regulate C1QA and C1QC expression in atheroscler

Why do systemic anti-inflammatory drugs fail in AD despite cardiovascular effica

What determines the specificity of calcium-dependent PPP3/calcineurin activation

What are the specific molecular mechanisms by which C1Q components drive atheros

What determines P2RY12 receptor expression/activity specifically in VSMCs during

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

How do perivascular cells specifically recognize and respond to amyloid-β to upr

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What is the therapeutic window between tau propagation inhibition and essential

Quantitative proteomics of the aging synapse in early Alzheimer disease

Immune atlas neuroinflammation analysis in neurodegeneration

Immune atlas neuroinflammation analysis in neurodegeneration

Perivascular spaces and glymphatic clearance failure in AD

4R-tau strain-specific spreading patterns in PSP vs CBD

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Perivascular spaces and glymphatic clearance failure in AD

Related Papers (20)