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PGC-1α knockout effects on PV+ interneuron maturation

experiment Created: 2026-04-06 12:33:34 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-e1440f14-445d-4c66-8f56-7
🧫 Experiment Protocol Animal Model
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Related Entities
PPARGC1A
Metadata
experiment_typeanimal_model
protocolConditional knockout with comprehensive phenotypic analysis
expected_outcomesImpaired structural, electrophysiological, synaptic, and metabolic maturation
success_criteriaSignificant defects in multiple maturation parameters
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:33:34.107643
source_pmid40669459
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:33:34.129507'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (29)
derives_from📄A postnatal molecular switch drives activity-dependent matur100%
related🧫PGC-1α expression analysis during PV+ interneuron developmen100%
related🧫Activity-dependent regulation of PGC-1α in PV+ interneurons100%
related🧪Perforant Path Presynaptic Terminal Protection Strategy100%
mentions📖PPARGC1A Gene80%
related📖PPARGC1A Gene72%
mentions📖PGC-1α Mitochondrial Biogenesis Comparison — AD/PD/ALS/FTD/H70%
mentions📖PGC-1α and Mitochondrial Biogenesis Therapies for Parkinson&70%
mentions📖PGC-1α Protein70%
mentions📖proteins-pgc-1a-protein70%
mentions📖PGC-1α (PPARGC1A)70%
mentions📖PGC-1 Alpha70%
mentions📖PGC-1β Protein70%
mentions📖PGC-1α Activator Therapy for Neurodegeneration70%
mentions📖PGC-1α (PPARGC1A) Targeted Therapies in Neurodegeneration70%
related📖PGC-1α Mitochondrial Biogenesis Comparison — AD/PD/ALS/FTD/H63%
related📖PGC-1α and Mitochondrial Biogenesis Therapies for Parkinson&63%
related📖PGC-1α Protein63%
related📖proteins-pgc-1a-protein63%
related📖PGC-1α (PPARGC1A)63%
related📖PGC-1 Alpha63%
related📖PGC-1β Protein63%
related📖PGC-1α Activator Therapy for Neurodegeneration63%
related📖PGC-1α (PPARGC1A) Targeted Therapies in Neurodegeneration63%
mentions📖Interneurons60%
mentions📖researchers60%
related🧪Perforant Path Presynaptic Terminal Protection Strategy60%
related📖Interneurons54%
related📖researchers54%

💬 Discussion