gene

PPARGC1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPARGC1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

994Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

PPARGC1A is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with ALS, Als, Alzheimer's disease. Connected to 505 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	PPARGC1A
Full Name	PPARG Coactivator 1 Alpha
Chromosome	4p15.31
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	PPARGC1A encodes PGC-1α (PPAR gamma coactivator 1-alpha), a transcriptional coactivator that serves as a master regulator of mitochondrial biogenesis and cellular energy metabolism.
Mechanism of Action	Small molecule modulator of transcriptional coactivator function
Primary Expression	tissues with high metabolic demand: - Brain: Neurons (especially in substantia nigra, hippocampus), [astrocytes](/entities/as
Druggability	Low (0.43)
Clinical Stage	Approved
Pathways	Apoptosis, Autophagy, Cell Cycle, Er Stress, Ferroptosis
UniProt ID	Q9UBX2
NCBI Gene ID	10891
Ensembl ID	ENSG00000109819
OMIM	604517
GeneCards	PPARGC1A
Human Protein Atlas	PPARGC1A
Associated Diseases	ALS, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, CANCER
Known Drugs/Compounds	reactive oxygen species, THYROID_HORMONE, Aloe-emodin, Kaixinsan, glitazones, piperine
Interactions	PRKAA1, ATG10, SIRT1, DNM1L, BAX, LC3
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Perforant Path Presynaptic Terminal Protection Str PGC1α Activation in PV+ Interneurons Bypasses Mito
KG Connections	992 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PPARGC1A — AlphaFold Q9UBK2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PPARGC1A["PPARGC1A"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PPARGC1A["PPARGC1A"] -->|"interacts"| PRKAA1["PRKAA1"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| SLC16A2["SLC16A2"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| RELN["RELN"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| MAP6["MAP6"]
    PPARGC1A["PPARGC1A"] -->|"co discussed"| HCN1["HCN1"]
    PRKAA1_1["PRKAA1"] -->|"interacts"| PPARGC1A["PPARGC1A"]
    FOXP3["FOXP3"] -->|"co discussed"| PPARGC1A["PPARGC1A"]
    TNFA["TNFA"] -->|"co discussed"| PPARGC1A["PPARGC1A"]
    style PPARGC1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (619)

Target	Relation	Type	Str
PGC1A	encodes	protein	0.95
Mitochondrial Biogenesis	regulates	process	0.95
Mitochondrial Biogenesis	mediates	process	0.95
Parvalbumin Interneuron Maturation	mediates	process	0.95
Mitochondrial Biogenesis	involved_in	process	0.95
BACE1	regulates	gene	0.95
mitochondrial biogenesis	promotes	process	0.95
Oxidative Phosphorylation	mediates	pathway	0.95
Alzheimer'S Disease	downregulates	disease	0.95
SQSTM1	regulates	protein	0.90
autophagy	activates	pathway	0.90
mitochondrial biogenesis	regulates	pathway	0.90
abdominal aortic aneurysm	protects_against	disease	0.90
PPARA	activates	gene	0.90
PPARD	activates	gene	0.90
kynurenine aminotransferases	contributes_to	protein	0.90
depression	protects_against	disease	0.90
fatty acid oxidation	associated_with	pathway	0.90
lipid droplet accumulation	inhibits	phenotype	0.90
oxidative phosphorylation	associated_with	pathway	0.90
ATP production	contributes_to	pathway	0.90
cancer metastasis	associated_with	disease	0.90
Mitochondrial Biogenesis	activates	process	0.90
Reactive Oxygen Species Synthesis	regulates	process	0.90
Inflammatory Cytokines	regulates	process	0.90
NRF2	activates	protein	0.90
Cancer Cell Invasion	contributes_to	phenotype	0.90
Pv+ Interneuron	regulates	cell_type	0.90
Parvalbumin interneuron electrophysiological properties	drives	phenotype	0.90
Parvalbumin interneuron structural development	promotes	phenotype	0.90
amyloid-beta	inhibits	protein	0.90
senescence	inhibits	phenotype	0.90
lipid metabolism	regulates	pathway	0.90
Reactive Oxygen Species	regulates	process	0.90
Metastasis	contributes_to	process	0.90
Amyloid-Beta	downregulates	protein	0.90
Alzheimer's Disease	therapeutic_target	disease	0.90
Mitochondrial Pool	associated_with	phenotype	0.85
WNT/β-Catenin Signaling	inhibits	pathway	0.85
Hepatocellular Carcinoma Progression	inhibits	disease	0.85
Structural Maturation	promotes	phenotype	0.85
Electrophysiological Maturation	promotes	phenotype	0.85
Synaptic Maturation	promotes	phenotype	0.85
Metabolic Maturation	promotes	phenotype	0.85
Terminal Differentiation	involved_in	process	0.85
Electrophysiological Properties	regulates	phenotype	0.85
Synaptic Function	regulates	phenotype	0.85
Metabolic Features	regulates	phenotype	0.85
Structural Properties	regulates	phenotype	0.85
NRF	interacts_with	protein	0.85

Incoming (375)

Source	Relation	Type	Str
IRE1A	degrades	protein	0.95
SIRT1	interacts_with	protein	0.90
SIRT1	modifies	protein	0.90
TFEB	activates	gene	0.90
Neuronal activity	activates	process	0.90
h-76888762	targets_gene	hypothesis	0.90
h-b0cda336	targets_gene	hypothesis	0.90
h-4c3210de	targets_gene	hypothesis	0.90
TFEB	upregulates	protein	0.85
CLU	associated_with	protein	0.85
ASPSCR1	binds	protein	0.85
CREB1	upregulates	gene	0.85
PRKAA2	activates	gene	0.85
METTL3	downregulates	gene	0.85
WTAP	downregulates	gene	0.85
exercise	activates	phenotype	0.80
h-76888762	targets	hypothesis	0.80
h-b0cda336	targets	hypothesis	0.80
Metformin	upregulates	drug	0.80
Prkaa2	activates	protein	0.80
aging	inhibits	phenotype	0.80
IRE1A	inhibits	gene	0.72
ACTB	regulates	gene	0.70
CAT	regulates	gene	0.70
CTSD	regulates	gene	0.70
SQSTM1	associated_with	gene	0.70
P62	associated_with	gene	0.70
Aloe-emodin	activates	drug	0.70
Kaixinsan	activates	drug	0.70
amyloid beta	inhibits	protein	0.70
PPARG	regulates	protein	0.70
PPARγ	activates	protein	0.70
glitazones	activates	drug	0.70
piperine	activates	drug	0.70
GLP-1	regulates	protein	0.70
Lactiplantibacillus plantarum SG5	activates	drug	0.70
AMPK	regulates	protein	0.70
FBXW7	inhibits	gene	0.70
MPTP	inhibits	drug	0.70
MITOCHONDRIA	activates	gene	0.70
CANCER	regulates	gene	0.70
ATG	activates	gene	0.70
rapamycin	targets	drug	0.70
metformin	targets	drug	0.70
TFEB	regulates	gene	0.64
CLU	interacts_with	gene	0.64
THYROID_HORMONE	activates	drug	0.64
METTL3	inhibits	gene	0.64
WTAP	inhibits	gene	0.64
METFORMIN	activates	drug	0.64

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Perforant Path Presynaptic Terminal Protection Strategy	0.484	neurodegeneration	Selective vulnerability of entorhinal co
PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
A postnatal molecular switch drives activity-dependent maturation of parvalbumin [PMID:40669459]	Moissidis M, Abbasova L, Selten M, Alis	Cell	2025	1
The Role of PGC1α in Alzheimer's Disease and Therapeutic Interventions. [PMID:34071270]	Mota BC, Sastre M	Int J Mol Sci	2021	1
Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with gl [PMID:33686286]	Habtemichael EN, Li DT, Camporez JP, Wes	Nat Metab	2021	1
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithel [PMID:31944172]	Matsuda J, Takahashi A, Takabatake Y, Sa	Autophagy	2020	1
Minutes of PPAR-γ agonism and neuroprotection. [PMID:32758586]	Prashantha Kumar BR, Kumar AP, Jose JA,	Neurochem Int	2020	1
Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614]	["Jin H", "Xue B", "Chen X", "Ma T", "Ma	Environmental pollution (Barki	2025	0
Lipidomic and Transcriptomic Reveals Variations in Lipid Deposition During Goose [PMID:41300406]	Zhang Q, Bai C, Zhang M, Yue B, Zhang J,	Biology	2025	0
Blueberry anthocyanins ameliorate arsenic-induced cognitive impairment in rats: [PMID:40663938]	Ma X, Liu Y, Ding B, Liu Y, Zhang Y, Wan	Phytomedicine : international	2025	0
Deciphering the PGC-1α-TFAM Axis in Parkinson's Disease (PD) - A Mechanism Appro [PMID:41454214]	Iyer M, Kinoshita M, Reddy DH, Babu HWS,	Molecular neurobiology	2025	0
Cardioprotective effects of the jiming formula on myocardial metabolism in Mice [PMID:40220403]	Fan X, Wei X, Wang W, Chai W, Xiao J, Ha	Phytomedicine : international	2025	0
Tang Bi formula alleviates diabetic sciatic neuropathy via AMPK/PGC-1α/MFN2 path [PMID:40646155]	["Yang C", "Yu H", "Zhou L", "Su H", "Li	Scientific reports	2025	0
Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 [PMID:37989471]	["Guo B", "Zheng C", "Cao J", "Luo F", "	Journal of advanced research	2024	0
Alcohol-related breast cancer in postmenopausal women - effect of CYP19A1, PPARG [PMID:27102200]	["Kopp T", "Jensen D", "Ravn-Haren G", "	BMC cancer	2016	0
Effect of rosiglitazone on peroxisome proliferator-activated receptor gamma gene [PMID:18954260]	["Mallon P", "Sedwell R", "Rogers G", "N	The Journal of infectious dise	2008	0

PPARGC1A

Understanding Entity Pages

Summary

Wiki Pages (21)

PPARGC1A Gene

Therapeutics

Neurons — Cell Type Hierarchy

NRF2 Oxidative Stress Pathway

Mitochondrial Quality Control

Mitochondrial Dysfunction in Neurodegeneration

Pathway Diagram

Outgoing (619)

Incoming (375)

Targeting Hypotheses (2)

Mentioning Analyses (3)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Digital biomarkers and AI-driven early detection of neurodegeneration

Selective vulnerability of entorhinal cortex layer II neurons in AD

Related Papers (14)

PPARGC1A

Understanding Entity Pages

Summary

Wiki Pages (21)

PPARGC1A Gene

Therapeutics

Neurons — Cell Type Hierarchy

NRF2 Oxidative Stress Pathway

Mitochondrial Quality Control

Mitochondrial Dysfunction in Neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway

mitophagy-defect

cynata-therapeutics

Mitochondria in Neurodegeneration

chromatin-remodeling-neurodegeneration

lmx1b

Biomarkers of Alzheimer Disease

Entorhinal Cortex

RXRG — Retinoid X Receptor Gamma

Biomarker-Therapeutic Development Nexus

Iduna Therapeutics

Nicotinamide Riboside

Muna Therapeutics

Biomarkers in Neurodegeneration

Irisin (FNDC5) - Exercise-Induced Myokine for Neurodegeneration

Pathway Diagram

Outgoing (619)

Incoming (375)

Targeting Hypotheses (2)

Mentioning Analyses (3)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Digital biomarkers and AI-driven early detection of neurodegeneration

Selective vulnerability of entorhinal cortex layer II neurons in AD

Related Papers (14)