🧫
Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Restoration
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-dlb-chol
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.904723Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['DLB'], 'diseases': ["Alzheimer's Disease"]} |
| model_system | human |
| summary | # Cholinergic System Dysfunction in DLB — Mechanisms and Therapeutic Restoration ## Background and Rationale Clinical trial testing whether muscarinic M1 receptor-selective agonism provides superior c |
| replication_status | replicated |
| methodology_notes | **Phase 1: Patient Recruitment and Baseline Assessment (Months 1-3)** • Recruit 120 participants: 40 DLB patients, 40 Alzheimer's disease patients, 40 age-matched healthy controls • Inclusion criteria |
| primary_outcome | CDR-SB change at 24 weeks with M1-selective agonist vs. cholinesterase inhibitor vs. placebo |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.904729'} |
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