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A protein complex network of Drosophila melanogaster.

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paper Created: By: unknown Quality: 50% ✓ SciDEX ID: paper-22036573
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A protein complex network of Drosophila melanogaster.
["Guruharsha K", "Rual J", "Zhai B", "Mintseris J", "Vaidya P", "Vaidya N", "Beekman C", "Wong C", "Rhee D", "Cenaj O"]
Cell PubMed DOI
Abstract

Determining the composition of protein complexes is an essential step toward understanding the cell as an integrated system. Using coaffinity purification coupled to mass spectrometry analysis, we examined protein associations involving nearly 5,000 individual, FLAG-HA epitope-tagged Drosophila proteins. Stringent analysis of these data, based on a statistical framework designed to define individual protein-protein interactions, led to the generation of a Drosophila protein interaction map (DPiM...

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