RNA Granule Nucleation Site Modulation

**Molecular Mechanism and Rationale** The pathological aggregation of TAR DNA-binding protein 43 (TDP-43) represents a critical hallmark of numerous neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and limbic-predominant age-related TDP-43 encephalopathy (LATE). Under physiological conditions, TDP-43 functions as a nuclear RNA-binding protein that regulates transcription, splicing, and mRNA stability. However, in disease states, TDP-43 u...