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Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss.
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ID: paper-39913247
📄 Paper Details
Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss.
Chemla A, Arena G, Sacripanti G, Barmpa K, Zagare A, Garcia P, Gorgogietas V, Antony P, Ohnmacht J, Baron A, Jung J, Lind-Holm Mogensen F, Michelucci A, Marzesco AM, Buttini M, Schmidt T, Grünewald A,
Abstract
The complex and heterogeneous nature of Parkinson's disease (PD) is still not fully understood. However, increasing evidence supports mitochondrial impairment as a major driver of neurodegeneration. Miro1, a mitochondrial GTPase encoded by the RHOT1 gene, is involved in mitochondrial transport, mitophagy and mitochondrial calcium buffering, and is therefore essential for maintaining mitochondrial homeostasis. Recently, Miro1 has been linked genetically and pathophysiologically to PD, further sup...
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📊 Evidence Profile
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