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Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.

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paper Created: By: unknown Quality: 50% ✓ SciDEX ID: paper-41678910
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Geum japonicum Thunb. var. Chinese-P.decorata H.Andres herbal pair ameliorates CIRI-induced neuronal injury by facilitating mitochondrial transfer via the CD38/Miro1 signaling pathway.
["Sun F", "She R", "Yang T", "Chen B", "Liao Z", "Liao J", "Mei Z"]
Phytomedicine : international journal of phytotherapy and phytopharmacology PubMed DOI
Abstract

BACKGROUND: Cerebral ischemia-reperfusion injury (CIRI) leads to severe mitochondrial dysfunction, which is a critical trigger of widespread neuronal apoptosis. Therefore, restoring mitochondrial homeostasis represents a key strategy for neuroprotection. Clinical observations suggest that the herbal pair Geum japonicum Thunb. var. chinense-P. decorata H. Andres (GJ-PD) shows therapeutic advantages in alleviating CIRI. However, its precise neuroprotective effects and underlying molecular mechanis...

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