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Boronophenylalanine-Mediated Boron Neutron Capture Therapy Confers Selective Killing of Cervical Cancer by Exploiting DNA Repair Deficiency.
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ID: paper-41817167
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Boronophenylalanine-Mediated Boron Neutron Capture Therapy Confers Selective Killing of Cervical Cancer by Exploiting DNA Repair Deficiency.
["Zhang L", "Quan R", "Huang H", "Wu M", "Wang W", "Zhang L", "Gu L", "Dai Z"]
Abstract
OBJECTIVE: Boron neutron capture therapy (BNCT) is an emerging binary targeted radiotherapy modality. This study evaluates the therapeutic potential of boronophenylalanine (BPA)-mediated BNCT in cervical cancer and to elucidate its underlying molecular mechanisms. METHODS: A comprehensive set of in vitro and in vivo approaches was employed using cervical cancer cell lines (HeLa, SiHa) and normal cervical epithelial cells (H8). The experimental techniques included clonogenic assays, flow cytometr...
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