Mitochondrial Transfer Pathway Enhancement

**Molecular Mechanism and Rationale** The mitochondrial transfer pathway enhancement strategy targets the fundamental cellular dysfunction underlying neurodegeneration by amplifying endogenous astrocyte-mediated repair mechanisms. Central to this approach is MIRO1 (Mitochondrial Rho GTPase 1), a critical regulator of mitochondrial transport that facilitates the movement of healthy mitochondria from neuroprotective A2 astrocytes to dysfunctional A1 astrocytes. MIRO1 functions as an adaptor prote...