UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylation and Degradation of NLRP3.

OBJECTIVE: Coronary heart disease (CHD), a major cardiovascular disorder, involves myocardial injury, inflammation, and fibrosis. NLRP3 inflammasome-driven pyroptosis plays a critical role in CHD progression. Although the ubiquitin-conjugating enzyme E2I (UBE2I) regulates protein SUMOylation, its function in CHD remains poorly understood. This study explores the expression and role of UBE2I in CHD, specifically examining its potential to mitigate myocardial injury and fibrosis via regulation of ...