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Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.

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paper Created: By: unknown Quality: 50% ✓ SciDEX ID: paper-40562635
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Perioperative polygenic and APOE-based genetic risk assessment for neurocognitive disorders: a biobank study.
Thedim M, Hu J, Maher M, Wiener-Kronish J, Saxena R et al.
Br J Anaesth PubMed DOI
Abstract

BACKGROUND: Preoperative risk assessment is a critical step in developing targeted preventive and therapeutic strategies. Although genetic biomarkers have shown considerable promise in assessing and stratifying dementia risk, their application in the perioperative period remains unexplored. Given the recognised effects of surgery and anaesthesia on perioperative cognitive trajectories, this study aimed to evaluate the preoperative neurocognitive genetic risk profiles of a surgical population and...

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