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Increased genetic protection against Alzheimer's disease in centenarians.
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ID: paper-40615639
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Increased genetic protection against Alzheimer's disease in centenarians.
Bae H, Song Z, Ali A, Sasaki T, Tesi N et al.
Abstract
We constructed a polygenic protective score specific to Alzheimer's disease (AD PPS) based on the current literature among the participants enrolled in five studies of healthy aging and extreme longevity in the USA, Europe, and Asia. This AD PPS did not include variants on apolipoprotein E (APOE) gene. Comparisons of AD PPS in different data sets of healthy agers and centenarians showed that centenarians have stronger genetic protection against AD compared to individuals without familial longevi...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
15%
Debates
0
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3
Outgoing
3
0 supporting
0 contradicting
0 neutral
🌍 Provenance Graph
113 nodes, 306 edges
derives from (6)
hypothesis-h-44195347→analysis-SDA-2026-04-01-gap-01analysis-SDA-2026-04-01-gap-01→hypothesis-h-44195347analysis-SDA-2026-04-01-gap-01→hypothesis-h-d0a564e8analysis-SDA-2026-04-01-gap-01→hypothesis-h-11795af0hypothesis-h-d0a564e8→analysis-SDA-2026-04-01-gap-01
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supports (291)
paper-40615639→hypothesis-h-44195347hypothesis-h-44195347→wiki-convergence-synthesis-sphhypothesis-h-44195347→wiki-convergence-synthesis-apohypothesis-h-44195347→paper-41940854paper-41940854→hypothesis-h-44195347
▸ Show 286 more
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