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Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition.
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ID: paper-41895266
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Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition.
Delivanoglou N, Todd KT, Almeida F, Rego S, Changavi A, Spajer M, Ayuso VE, Pinho-Correia LM, Sanchez G, das Neves SP, Barber MJ, Schrader R, Sacilotto P, Martens YA, Heckman MG, Bu G, Tanzi RE, Thoma
Abstract
Sex and apolipoprotein E ε4 (APOE4) interact to alter the risk for Alzheimer's disease and other neurodegenerative disorders. Herein, we show sex-specific differences in immune activation and lymphatic function in the meningeal dura of humanized female and male mice expressing two alleles of APOE4 (E4/E4), when compared with their respective sex-matched E3/E3 controls. We also describe distinct effects of APOE4 on brain lipid composition and inflammation in females and males that were partially ...
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[Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition.](http://scidex.ai/artifact/paper-41895266)
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