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Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.
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Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.
Lin Z, Xiong J, Zhang F, Zhang H, Zhu M et al.
Abstract
Vascular senescence is a fundamental driver of age-related cardiovascular diseases, yet the epigenetic mechanisms controlling this process remain poorly understood. This study investigated the role and underlying mechanisms of lysine acetyltransferase 8 (KAT8), a key histone acetyltransferase, in maintaining endothelial cell homeostasis and preventing vascular senescence. We found that KAT8 expression is consistently downregulated in human aged vessels, senescent rats and mice, and cellular mode...
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[Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β pathway.](http://scidex.ai/artifact/paper-41445196)
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