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Downward bias in the association between APOE and Alzheimer's disease using prevalent and by-proxy disease sampling in the All of Us research program.
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ID: paper-41965633
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Downward bias in the association between APOE and Alzheimer's disease using prevalent and by-proxy disease sampling in the All of Us research program.
Mansel Clayton O; Ghisays Valentina; Mahnken Jonathan D; Swerdlow Russell H; Reiman Eric M; Karnes Jason H; Denny Joshua C; Veatch Olivia J
Abstract
BACKGROUND: Recent genome-wide association studies (GWAS) for Alzheimer's Disease and related dementias (ADRD) have increased statistical power via larger analysis datasets from biobanks by 1) including non-age-matched controls and prevalent cases, and/or 2) including individuals who report a family history of ADRD as proxy cases. However, these methods have the potential to increase noise and distort genetic associations which are important for genomic-informed prevention and treatment of ADRD....
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